7073-36-1

Basic information

• Product Name: 2-CHLORO-4-NITROBENZOYL CHLORIDE
• Synonyms: Benzoyl chloride, 2-chloro-4-nitro-;2-CHLORO-4-NITROBENZOYL CHLORIDE;4-Nitro-2-chlorobenzoyl chloride
• CAS NO: 7073-36-1
• Molecular Formula: C₇H₃Cl₂NO₃
• Molecular Weight: 220.01
• EINECS: 230-367-4
• Product Categories: Aromatic Halides (substituted)
• Mol File: 7073-36-1.mol
• Article Data: 34

Chemical Properties

• Melting Point: 26°C
• Boiling Point: 165°C 20mm
• Flash Point: 165°C/20mm
• Appearance: /
• Density: 1.575 g/cm³
• Vapor Pressure: 0.00121mmHg at 25°C
• Refractive Index: 1.5950
• Solubility: soluble in Toluene
• Sensitive: Moisture Sensitive
• BRN: 519794
• CAS DataBase Reference: 2-CHLORO-4-NITROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-NITROBENZOYL CHLORIDE(7073-36-1)
• EPA Substance Registry System: 2-CHLORO-4-NITROBENZOYL CHLORIDE(7073-36-1)

Safety Data

• Hazard Codes: Xi
• Statements: 34-41
• Safety Statements: 26-36/37/39-45-39
• RIDADR: 3265
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 7073-36-1(Hazardous Substances Data)

Usage

Description

2-Chloro-4-nitrobenzoyl chloride is an organic compound characterized by its molecular structure featuring a chlorine atom at the 2nd position and a nitro group at the 4th position on a benzoyl chloride backbone. It is a versatile chemical intermediate used in the synthesis of various pharmaceutical compounds and organic materials.

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-nitrobenzoyl chloride is used as a chemical intermediate for the synthesis of benzoxazole derivatives, which serve as interleukin-6 antagonists. These antagonists are crucial in the development of medications targeting inflammatory diseases and conditions where interleukin-6 plays a significant role in the pathology.

InChI:InChI=1/C7H3Cl2NO3/c8-6-3-4(10(12)13)1-2-5(6)7(9)11/h1-3H

Upstream product

• 99-60-5 2-chloro-4-nitrobenzoic acid 
• 61747-12-4 (4-amino-2-chlorophenyl)(phenyl)methanone 

Downstream Products

• 106737-50-2 2-chloro-4-nitro-benzoic acid-(2-methoxy-phenyl ester) 
• 69819-49-4 2-chloro-4-nitro-N-(5-nitro-thiazol-2-yl)-benzamide 
• 105550-87-6 5-(2-cloro-4-nitrobenzoil)tiofen-2-acetonitrile 
• 111461-00-8 (2-Chloro-4-nitro-phenyl)-(5-hydroxy-3-methyl-isoxazol-4-yl)-methanone 
• 105550-86-5 5-(2-cloro-4-nitrobenzoil)tiofen-2-acetato di metile 
• 90531-57-0 2-Chloro-4-nitro-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 73672-83-0 2-Chloro-4-nitro-benzoic acid 6-oxo-2-phenyl-6H-[1,3]thiazin-4-yl ester 
• 61051-44-3 5-(2-chloro-4-nitrophenyl)-3-(2-furanyl)-1,2,4-oxadiazole 
• 50274-64-1 (2-chloro-4-nitrophenyl)(4-chlorophenyl)-methanone 
• 124894-95-7 2-chloro-4-nitrohippuric acid 
• 33663-73-9 (2-chloro-4-nitrophenyl)(phenyl)methanone 
• 37883-93-5 (2-Chloro-4-nitro-phenyl)-(2-methoxy-5-methyl-phenyl)-methanone 
• 37883-96-8 (2-Chloro-4-nitro-phenyl)-(2,5-dimethoxy-phenyl)-methanone 
• 174536-60-8 2-(2-Chloro-4-nitrophenyl)benzothiazole 

Relevant articles and documents

Synthesis and Antiproliferative Activities of Novel Substituted 5-Anilino-α-Glucofuranose Derivatives

In order to find novel antitumor candidate agents with high efficiency and low toxicity, 14 novel substituted 5-anilino-α-glucofuranose derivatives have been designed, synthesized and evaluated for antiproliferative activities in vitro. Their structures were characterized by NMR (1H and 13C) and HR-MS, and configuration (R/S) at C(5) was identified by two-dimensional 1H,1H-NOESY-NMR spectrum. Their antiproliferative activities against human tumor cells were investigated by MTT assay. The results demonstrated that most of the synthesized compounds had antiproliferative effects comparable to the reference drugs gefitinib and lapatinib. In particular, (5R)-5-O-(3-chloro-4-{[5-(4-fluorophenyl)thiophen-2-yl]methyl}anilino)-5-deoxy-1,2-O-(1-methylethylidene)-α-glucofuranose (9da) showed the most potent antiproliferative effects against SW480, A431 and A549 cells, with IC50 values of 8.57, 5.15 and 15.24 μm, respectively. This work suggested 5-anilino-α-glucofuranose as an antitumor core structure that may open a new way to develop more potent anti-cancer agents.

Design and synthesis of arylamidine derivatives as serotonin/norepinephrine dual reuptake inhibitors

To improve the in vivo antidepressant activity of previously reported serotonin (5-HT) and norepinephrine (NE) dual reuptake inhibitors, three series of arylamidine derivatives were designed and synthesized. The in vitro 5-HT and NE reuptake inhibitory activities of these compounds were evaluated, and compound II-5 was identified as the most potent 5-HT (IC50 = 620 nM) and NE (IC50 = 10 nM) dual reuptake inhibitor. Compound II-5 exhibited potent antidepressant activity in the rat tail suspension test and showed an acceptable safety profile in a preliminary acute toxicity test in mice. Our results show that these arylamidine derivatives exhibit potent 5-HT/NE dual reuptake inhibition and should be explored further as antidepressant drug candidates.

Diarylamino glucosan derivative, and preparation method and anti-tumor purpose thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to a diarylamino glucosan derivative, and a preparation method and an anti-tumor purpose thereof, wherein the diarylamino glucosan derivative particularly relates to a compound shown as a formula I. The invention also relates to the preparation method of the diarylamino glucosan derivative, and the purpose of the diarylamino glucosan derivative in an aspect of preparing medicine for treating tumor diseases. The diarylamino glucosan derivative particularly has the obvious inhibition effects on human skin quamous cell carcinoma cells, human lung carcinoma cells and human colon cancer cells.