7073-42-9

Basic information

• Product Name: 3-Chloro-4-Methoxyacetanilide
• Synonyms: 3-Chloro-4-Methoxyacetanilide;3'-Chloro-4'-methoxyacetoanilide;N-(3-Chloro-4-methoxyphenyl)acetamide
• CAS NO: 7073-42-9
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.64
• Mol File: 7073-42-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 366.8°C at 760 mmHg
• Flash Point: 175.6°C
• Appearance: /
• Density: 1.259g/cm³
• Vapor Pressure: 1.43E-05mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 3-Chloro-4-Methoxyacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-Methoxyacetanilide(7073-42-9)
• EPA Substance Registry System: 3-Chloro-4-Methoxyacetanilide(7073-42-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7073-42-9(Hazardous Substances Data)

Usage

Description

3-Chloro-4-Methoxyacetanilide, also known as N-(3-Chloro-4-Methoxyphenyl)acetamide, is an acetanilide derivative featuring a chlorine atom and a methoxy group attached to the phenyl ring. This chemical compound is widely recognized for its role in the synthesis of pharmaceuticals and organic compounds, making it a valuable and versatile component in the chemical industry.

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-Methoxyacetanilide is utilized as an intermediate in the production of anti-inflammatory and analgesic drugs. Its unique structure allows it to be a key component in the development of medications aimed at reducing inflammation and pain.
Used in Organic Chemical Reactions:
As a reagent, 3-Chloro-4-Methoxyacetanilide is employed in various organic chemical reactions, facilitating the synthesis of a range of organic compounds. Its properties make it a useful tool for chemists in the development of new chemical entities.
Used in Synthesis of Complex Organic Molecules:
3-Chloro-4-Methoxyacetanilide also serves as a building block in the synthesis of complex organic molecules. Its structural features contribute to the creation of intricate chemical structures that are vital in numerous applications across different industries.

InChI:InChI=1/C9H10ClNO2/c1-6(12)11-7-3-4-9(13-2)8(10)5-7/h3-5H,1-2H3,(H,11,12)

Upstream product

• 631-61-8 ammonium acetate 
• 64-19-7 acetic acid 
• 5345-54-0 3-chloro-4-methoxyaniline 
• 766-51-8 2-Chloroanisole 
• 4920-79-0 2-chloro-4-nitroanisole 
• 75-36-5 acetyl chloride 
• 51-66-1 4-methoxyacetanilide 
• 108-24-7 acetic anhydride 

Downstream Products

• 38608-06-9 5-chloro-4-methoxy-o-phenylenediamine 
• 119927-90-1 3-chloro-4,4-dimethoxycyclohexa-2,5-dien-1-one 
• 1381862-02-7 N-acetyl-3-chloro-p-benzoquinone imine dimethyl acetal 
• 33234-37-6 6-amino-2-chloro-3-methoxy-benzoic acid 
• 85778-01-4 6-chloro-5-methoxy-isatin 
• 1026083-32-8 1-Azido-5-chloro-4-methoxy-2-nitro-benzene 
• 160088-54-0 5-Chloro-4-methoxy-2-nitroaniline 
• 3964-54-3 3-chloro-4-hydroxyacetanilide 
• 160088-53-9 N-(5-chloro-4-methoxy-2-nitrophenyl)-acetamide 
• 130420-87-0 hydroxyimino-acetic acid-(3-chloro-4-methoxy-anilide) 
• 220587-30-4 N-acetyl-3-chloro-4-tetrahydropyranyloxy-aniline 
• 174668-87-2 3-chloro-4-tetrahydropyranyloxy-aniline 
• 685534-98-9 3-[2-(acetylamino)-4-chloro-5-methoxyphenyl]-2-(2E)-propenoic acid 

Relevant articles and documents

General rhodium-catalyzed oxidative cross-coupling reactions between anilines: Synthesis of unsymmetrical 2,2′-diaminobiaryls

Described herein is a dual chelation-assisted RhCl3-catalyzed oxidative C-H/C-H cross-coupling reaction of aniline derivatives. The highlight of this methodology is the chemo- and regioselective cross-coupling between electronically similar substrates, which represents a highly challenging task in oxidative Ar-H/Ar-H cross-coupling reactions. Furthermore, this Cp?-free catalytic reaction tolerates a range of functional groups and requires only a low molar ratio of coupling partners. These features expedite the synthesis of unsymmetrical 2,2′-diaminobiaryls.

PHOSPHOGLYCERATE KINASE INHIBITORS

Disclosed are compounds of formula (I) or pharmaceutical acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined in the description. Disclosed are also the methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as phosphoglycerate kinase.

Pd-catalyzed ortho-selective oxidative coupling of halogenated acetanilides with acrylates

Coupling of different halogenated acetanilides with acrylates using Pd-catalyzed ortho-selective C-H bond activation is reported. The yields of coupled products are low to high depending on the substrate. In general, arenes with electron-rich substituents like methoxy and methyl groups gave higher yields of the coupled products. The presence of the halogen substituent did not interfere with the activation process under these conditions.