70862-11-2 Usage
Description
Thermospermine is a polyamine natural product that is structurally similar to spermine. It was first isolated from the extreme thermophile, Thermus thermophilus, which is where its name originates. Thermospermine is characterized by the substitution of a hydrogen attached to one nitrogen with a 3-aminoprop-1-yl group, and a hydrogen attached to the other nitrogen with a 4-aminobut-1-yl group.
Uses
Used in Pharmaceutical Industry:
Thermospermine is used as a potential therapeutic agent for various applications in the pharmaceutical industry. Its unique structure and properties make it a promising candidate for the development of new drugs and treatments.
Used in Research Applications:
Thermospermine is also used as a research tool to study the role of polyamines in biological processes. Its isolation from Thermus thermophilus, an extreme thermophile, provides insights into the adaptation mechanisms of organisms in extreme environments and can contribute to the understanding of polyamine functions in stress response and cellular regulation.
Used in Cosmetic Industry:
Thermospermine may also find applications in the cosmetic industry due to its potential benefits for skin health and anti-aging properties. Its unique structure and natural origin make it an attractive ingredient for cosmetic products aimed at promoting skin rejuvenation and maintaining skin integrity.
Check Digit Verification of cas no
The CAS Registry Mumber 70862-11-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,8,6 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 70862-11:
(7*7)+(6*0)+(5*8)+(4*6)+(3*2)+(2*1)+(1*1)=122
122 % 10 = 2
So 70862-11-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H26N4/c11-5-1-2-7-13-9-4-10-14-8-3-6-12/h13-14H,1-12H2
70862-11-2Relevant articles and documents
Practical synthesis of spermine, thermospermine and norspermine
Kariya, Yuka,Asanuma, Yuta,Inai, Makoto,Asakawa, Tomohiro,Ohashi-Ito, Kyoko,Fukuda, Hiroo,Egi, Masahiro,Kan, Toshiyuki
, p. 1403 - 1407 (2016/09/09)
Polyamines, such as spermine (1), thermospermine (2) and norspermine (3), are widely distributed in nature, and have multiple biological activities. In addition, many of their conjugates have potential for pharmacological use. Here, we present a solid-phase synthesis using our nitrobenzenesulfonyl (Ns) strategy, which can provide 1, 2 and 3 on a gram scale. This approach should be suitable for facile construction of a diverse library of polyamines.
Substrate binding characteristics of the active site of spermidine dehydrogenase from Serratia marcescens
Okada,Kawashima,Imahori
, p. 1235 - 1243 (2007/10/05)
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