7087-60-7Relevant articles and documents
Novel pazopanib derivatives and pharmaceutical composition comprising the same
-
Paragraph 0095; 0097; 0098; 0099, (2017/05/10)
The present invention relates to novel pazopanib derivatives or a salt thereof having inhibition activities of angiogenesis and epidermal growth factors at the same time, and to a pharmaceutical composition comprising the same as an active ingredient. The pazopanib derivatives have inhibition activities of angiogenesis and epidermal growth factors at the same time unlike pazopanib, thereby more effectively treating and preventing EGFR-related cancer diseases such as lung cancer, colon cancer or breast cancer through a multiple aim target, and effectively treating and preventing non-small-cell lung cancer which Iressa or Tarceva cannot have an effect on.COPYRIGHT KIPO 2017
Development of CXCR3 antagonists. Part 4: Discovery of 2-amino-(4-tropinyl)quinolines
Knight, Roland L.,Allen, Daniel R.,Birch, Helen L.,Chapman, Gayle A.,Galvin, Frances C.,Jopling, Louise A.,Lock, Christopher J.,Meissner, Johannes W.G.,Owen, David A.,Raphy, Gilles,Watson, Robert J.,Williams, Sophie C.
, p. 629 - 633 (2008/09/17)
The synthesis and biological evaluation of a novel series of 2-aminoquinoline substituted piperidines and tropanes incorporating a homotropene moiety is herein described. The series exhibits potent antagonism of the CXCR3 receptor and superior physicochem