709028-64-8Relevant articles and documents
Phenylacetic acid derivatives as hPPAR agonists
Santini, Conrad,Berger, Gregory D.,Han, Wei,Mosley, Ralph,MacNaul, Karen,Berger, Joel,Doebber, Thomas,Wu, Margaret,Moller, David E.,Tolman, Richard L.,Sahoo, Soumya P.
, p. 1277 - 1280 (2003)
Beginning with the weakly active lead structure 1, a new series of hPPAR agonists was developed. In vivo glucose and triglyceride lowering activity was obtained by homologation and oxamination to 3, then conversion to substituted benzisoxazoles 4 and 5. F