709040-07-3Relevant articles and documents
Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S) - A potential mechanism for the anti-cancer effects of ibuprofen
Woodman, Timothy J.,Wood, Pauline J.,Thompson, Andrew S.,Hutchings, Thomas J.,Steel, Georgina R.,Jiao, Ping,Threadgill, Michael D.,Lloyd, Matthew D.
supporting information; experimental part, p. 7332 - 7334 (2011/08/06)
Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs; 'profens'), such as ibuprofen, is important for pharmacological activity. Several 2-APA-CoA esters were good racemisation substrates for human AMACR 1A, suggesting a common chiral inversion pathway for all 2-APAs and an additional mechanism for their anti-cancer properties.
