70967-90-7 Usage
Description
N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE, also known as MeOSuc-AAPV-pNA, is a highly sensitive peptide substrate that is specifically hydrolyzed by both human and mouse neutrophil elastase and proteinase 3 (PR3), but not by cathepsin G or chymotrypsin. It is used for evaluating the activity of these enzymes, which are important in understanding inflammatory autoimmune processes.
Uses
Used in Enzyme Activity Assays:
N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE is used as a substrate for the colorimetric detection of free p-nitroanilide at 405 nm, allowing for the quantification of enzyme activity. This is particularly useful in assays for neutrophil elastase and PR3, which play a role in inflammatory autoimmune processes.
Used in Research and Diagnostics:
In the field of research and diagnostics, N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE is used as a tool for studying the activity and regulation of neutrophil elastase and PR3. This can help in understanding the underlying mechanisms of inflammatory autoimmune diseases and potentially lead to the development of targeted therapies.
Used in Pharmaceutical Development:
N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE can be used in the development of drugs targeting neutrophil elastase and PR3. By monitoring the activity of these enzymes, researchers can assess the efficacy of potential therapeutic agents and optimize their development for the treatment of inflammatory autoimmune disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 70967-90-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,9,6 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 70967-90:
(7*7)+(6*0)+(5*9)+(4*6)+(3*7)+(2*9)+(1*0)=157
157 % 10 = 7
So 70967-90-7 is a valid CAS Registry Number.
InChI:InChI=1/C27H38N6O9/c1-15(2)23(30-18-8-10-19(11-9-18)33(40)41)26(38)31-25(37)20-7-6-14-32(20)27(39)17(4)29-24(36)16(3)28-21(34)12-13-22(35)42-5/h8-11,15-17,20,23,30H,6-7,12-14H2,1-5H3,(H,28,34)(H,29,36)(H,31,37,38)/t16-,17-,20-,23-/m0/s1
