70974-50-4

Basic information

• Product Name: 1-(azepan-1-yl)hexadecan-1-one
• CAS NO: 70974-50-4
• Molecular Formula: C₂₂H₄₃NO
• Molecular Weight: 337.5829
• Mol File: 70974-50-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 460.5°C at 760 mmHg
• Flash Point: 186.7°C
• Density: 0.894g/cm³
• Vapor Pressure: 1.16E-08mmHg at 25°C
• Refractive Index: 1.469
• CAS DataBase Reference: 1-(azepan-1-yl)hexadecan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(azepan-1-yl)hexadecan-1-one(70974-50-4)
• EPA Substance Registry System: 1-(azepan-1-yl)hexadecan-1-one(70974-50-4)

Safety Data

• Hazardous Substances Data: 70974-50-4(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

It is a compound derived from a ketone, which is a carbonyl functional group (C=O) bonded to two carbon-containing groups.

Explanation

The compound has a linear chain of 16 carbon atoms (alkyl chain) and a nitrogen-containing seven-membered ring (azepane ring) attached to it.

Explanation

The compound is used in various industries, including pharmaceuticals, organic synthesis, perfumes, and the food industry, due to its versatile chemical properties.

Explanation

The chemical properties of 1-(azepan-1-yl)hexadecan-1-one make it suitable for a wide range of applications in different industries, contributing to its commercial value.

Chemical Class

Ketone derivative

Structure

Contains a 16-carbon alkyl chain and a seven-membered azepane ring

Applications

Pharmaceutical production, organic synthesis, fragrance ingredient, and flavoring agent

Industrial and Commercial Uses

Versatile compound

Upstream product

• 57-10-3 1-hexadecylcarboxylic acid 
• 111-49-9 hexamethylene imine 
• 74058-64-3 1-(2-Thioxo-thiazolidin-3-yl)-hexadecan-1-one 

Relevant articles and documents

Dermal penetration enhancement profile of hexamethylenelauramide and its homologues: In vitro versus in vivo behavior of enhancers in the penetration of hydrocortisone

Several amides of cyclic amines were prepared and tested as penetration enhancers in the diffusion of various drugs through hairless mouse skin in vitro. Hexamethylenelauramide (hexahydro-1-lauroyl-1H-azepine) was selected as a broad spectrum penetration enhancer worthy of further study. Later, the duration of the effect of various enhancers on the penetration barrier in vivo was determined by evaluating the in vitro diffusion of hyrocortisone through skins that had been pretreated in vivo. We found that the longer the pretreatment, the smaller the amount of penetrated hydrocortisone. Furthermore, our results suggested that differences exist in the retention of various enhancers in living mouse skin. The in vitro pretreatment experiments revealed that the penetration through dead skin is slow compared with the penetration through living skin. Neither the nature of the receptor phase, nor the increased temperature of the in vitro experiments, explain the striking differences between the in vivo and the in vitro experiments. Finally, the penetration of hydrocortisone through the stratum corneum in the presence of enhancers, as well as the penetration of 1-dodecylhexahydro-2H-azepin-2-one (laurocapram), hexamethylenelauramide, and oleic acid, were determined using a stratum corneum stripping technique. More hydrocortisone penetrated through the stratum corneum during the first 3 h in the presence of hexamethylenelauramide than in the presence of laurocapram or oleic acid.

MONITORED AMINOLYSIS OF 3-ACYLTHIAZOLIDINE-2-THIONE : A NEW CONVENIENT SYNTHESIS OF AMIDE

3-Acylthiazolidine-2-thiones (1) were easily prepared and they were treated with several amines in dichloromethane to give amides 4 in very high yields within a short time.Aminoalcohols and aminophenols were selectively converted into acylaminoalcohols and acylaminophenols, respectively, by this reaction.One can monitor the reaction by disappearance of the yellow color of the starting material 1.Some amide alkaloids (15-18) have effectively been synthesized.