710-09-8

Basic information

• Product Name: Phosphonic acid, methyl-, methyl phenylmethyl ester
• Synonyms: Methyl-phosphorsaeure-benzylester-methylester;benzyl methyl methylphosphonate;Methylphosphonsaeure-benzylester-methylester;benzyl methyl methanephosphonate
• CAS NO: 710-09-8
• Molecular Formula: C9H13O3P
• Molecular Weight: 200.17100
• Mol File: 710-09-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, methyl-, methyl phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, methyl-, methyl phenylmethyl ester(710-09-8)
• EPA Substance Registry System: Phosphonic acid, methyl-, methyl phenylmethyl ester(710-09-8)

Safety Data

• Hazardous Substances Data: 710-09-8(Hazardous Substances Data)

Usage

General Description

Phosphonic acid, methyl-, methyl phenylmethyl ester is a compound that belongs to the group of phosphonic acid esters. It is commonly used as a flame retardant and plasticizer in polymer materials. This chemical is known for its high thermal stability and effectiveness in reducing the flammability of various products. It is also used in metal surface treatment and as a stabilizer in industrial processes. However, it is important to handle this chemical with caution as it can be harmful if inhaled or ingested, and it may cause skin and eye irritation upon contact. Proper safety measures and protective equipment should be used when working with this chemical.

Upstream product

• 538-60-3 dibenzyl hydrogen phosphite 
• 19236-58-9 dibenzyl methylphosphonate 
• 140-11-4 Benzyl acetate 
• 756-79-6 dimethyl methane phosphonate 
• 33472-04-7 dimethyl benzyloxycarbonylphosphonate 
• 5849-72-9 tetramethylammonium methylphosphonic acid methyl ester 
• 100-39-0 benzyl bromide 
• 676-97-1 methylphosphonic acid dichloroanhydride 
• 67-56-1 methanol 
• 100-51-6 benzyl alcohol 
• 186581-53-3 diazomethane 
• 101523-04-0 Methylphosphonic acid monobenzyl ester 

Downstream Products

• 166049-85-0 methylenebisphosphonic acid tribenzyl methyl ester 
• 503306-26-1 difluoromethylenebisphosphonic acid tribenzyl methyl ester 
• 86509-41-3 {3-[(2S,3R)-3-((S)-1-Hydroxy-ethyl)-4-oxo-azetidin-2-yl]-2-oxo-propyl}-phosphonic acid benzyl ester methyl ester 
• 86509-48-0 [(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3,7-dioxo-1-aza-bicyclo[3.2.0]hept-2-yl]-phosphonic acid benzyl ester methyl ester 
• 86509-50-4 [(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-methoxy-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-2-yl]-phosphonic acid benzyl ester methyl ester 
• 86509-39-9 (3-{(2S,3R)-3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester 
• 1066-52-0 methyl methylphosphonochloridate 
• 1066-53-1 methyl hydrogen methylphosphonate 
• 86530-02-1 (3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester 

Relevant articles and documents

Synthesis of phosphorus esters by transesterification mediated by N-heterocyclic carbenes (NHCs)

The versatile nucleophilic organic catalysts N-heterocyclic carbenes (NHCs) have been shown to effectively mediate the transesterification of phosphorus esters under mild conditions; user-friendly imidazolium salts can also be employed as pre-catalysts. T

Alkali metal alkoxide clusters: Convenient catalysts for the synthesis of methylphosphonates

Alkali metal alkoxides are good catalysts (1-8 mol %) for promoting the interchange reaction between carbonyl and phosphorus esters. This reactivity leads to convenient methodologies for the synthesis of symmetric and unsymmetric alkyl-substituted methylphosphonates from dimethyl methylphosphonate (DMMP). Reactions rates are high with initial turnover frequencies (N(t)) in excess of 1 x 106 h-1 observed and with KO(t)Bu > NaO(t)Bu > LiO(t)Bu. The reactions were sensitive to steric effects in the product methylphosphonates with reaction rates paralleling the size of the transferring alkoxide (n-alkyl > isoalkyl >> tert-alkyl). For the test reaction DMMP + isopropyl acetate, substitution kinetics were consistent with a scenario wherein each methoxide is replaced sequentially, and the substitution rate for the second displacement is substantially slower than the first. Kinetic studies on the first substitution process were indicative of a concentration dependent rate law; a scenario most easily accounted for by a coupled transesterification wherein alkoxide reversibly and independently adds to phosphonate and ester.

SYNTHESIS OF CARBAPENEM-3-PHOSPHONIC ACID DERIVATIVES

The synthesis of 6-(1-hydroxyethyl)-2-oxocarbapenem-3-phosphonic acid derivatives, starting from 3-iodomethyl-2-oxoazetidine is described.