71022-62-3

Basic information

• Product Name: PropanaMide, 2-Methyl-N-(2-phenylethyl)-
• Synonyms: PropanaMide, 2-Methyl-N-(2-phenylethyl)-;N-PHENETHYLISOBUTYRAMIDE
• CAS NO: 71022-62-3
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.26948
• Mol File: 71022-62-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 361.6°C at 760 mmHg
• Flash Point: 216.2°C
• Appearance: /
• Density: 0.982g/cm³
• Vapor Pressure: 2.04E-05mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: PropanaMide, 2-Methyl-N-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: PropanaMide, 2-Methyl-N-(2-phenylethyl)-(71022-62-3)
• EPA Substance Registry System: PropanaMide, 2-Methyl-N-(2-phenylethyl)-(71022-62-3)

Safety Data

• Hazardous Substances Data: 71022-62-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H17NO/c1-10(2)12(14)13-9-8-11-6-4-3-5-7-11/h3-7,10H,8-9H2,1-2H3,(H,13,14)

Upstream product

• 64-04-0 phenethylamine 
• 97-62-1 Ethyl isobutyrate 
• 563-83-7 ISOPROPYLAMIDE 
• 79-30-1 isobutyryl chloride 
• 79-31-2 isobutyric Acid 

Downstream Products

• 473996-33-7 (S)-N-(2-phenylbutyl)isobutyramide 
• 152971-88-5 (S)-1-isopropyl-1,2,3,4-tetrahydroisoquinoline 
• 152971-88-5 (-)-1-isopropyl-1,2,3,4-tetrahydroisoquinoline 
• 1344029-42-0 1-isopropyl-2-{[1-(2-phenylethyl)piperidin-4-yl]carbonyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 473996-37-1 (S)-N-Boc-N-(2-phenylbutyl)-isobutyramide 
• 473996-38-2 (S)-N-Boc-2-phenyl butylamine 
• 33603-06-4 (+)-1-amino-2-phenylbutane 
• 473996-32-6 (S)-N-(2-phenyl-4-pentenyl)isobutyramide 
• 473996-31-5 (S)-N-(2,3-diphenylpropyl)isobutyramide 

Relevant articles and documents

Efficiency Enhancement of a Photocatalytic Decarbonylation of an Aminocyclopropenone by Benzothiophene Substitution

To improve the efficiency of the photocatalytic decarbonylation of cyclopropenones, the effects of substituents on cyclopropenone were explored. A benzothiophene-substituted aminocyclopropenone exhibited significantly improved decarbonylation efficiency t

Biocatalytic N-Acylation of Amines in Water Using an Acyltransferase from Mycobacterium smegmatis

A straightforward one-step biocatalyzed synthesis of different N-acyl amides in water was accomplished using the versatile and chemoselective acyltransferase from Mycobacterium smegmatis (MsAcT). Acetylation of primary arylalkyl amines was achieved with a range of acetyl donors in biphasic systems within 1 hour and at room temperature. Vinyl acetate was the best donor which could be employed in the N-acetylation of a large range of primary amines in excellent yields (85–99%) after just 20 minutes. Other acyl donors (including formyl-, propionyl-, and butyryl-donors) were also efficiently employed in the biocatalytic N-acylation. Finally, the biocatalyst was tested in transamidation reactions using acetamide as acetyl donor in aqueous medium, reaching yields of 60–70%. This work expands the toolbox of preparative methods for the formation of N-acyl amides, describing a biocatalytic approach easy to accomplish under mild conditions in water. (Figure presented.).

Identification of an Imine Reductase for Asymmetric Reduction of Bulky Dihydroisoquinolines

A new imine reductase from Stackebrandtia nassauensis (SnIR) was identified, which displayed over 25- to 1400-fold greater catalytic efficiency for 1-methyl-3,4-dihydroisoquinoline (1-Me DHIQ) compared to other imine reductases reported. Subsequently, an efficient SnIR-catalyzed process was developed by simply optimizing the amount of cosolvent, and up to 15 g L-1 1-Me DHIQ was converted completely without a feeding strategy. Furthermore, the reaction proceeded well for a panel of dihydroisoquinolines, affording the corresponding tetrahydroisoquinolines (mostly in S-configuration) in good yields (up to 81%) and with moderate to excellent enantioselectivities (up to 99% ee).