71082-34-3

Basic information

• Product Name: AURORA 17729
• Synonyms: AURORA 17729;8-Methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester;Ethyl B-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
• CAS NO: 71082-34-3
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.25
• Mol File: 71082-34-3.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: AURORA 17729(CAS DataBase Reference)
• NIST Chemistry Reference: AURORA 17729(71082-34-3)
• EPA Substance Registry System: AURORA 17729(71082-34-3)

Safety Data

• Hazardous Substances Data: 71082-34-3(Hazardous Substances Data)

Usage

General Description

Aurora 17729 is a chemical compound developed by Aurora Fine Chemicals. As this is a proprietary substance developed by the company, specific details such as its chemical structure, properties, and potential uses are not publicly disclosed or easily accessible. The company specializes in creating a wide variety of chemicals for use in different fields such as pharmaceuticals, biotechnology, and agrochemicals. Therefore, it can be presumed that AURORA 17729 has potential applications within these areas.

Upstream product

• 104007-09-2 2-[(2-methoxyphenylamino)-methylene]-malonic acid diethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 40131-09-7 diethyl methoxymethylenemalonate 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 27568-05-4 4-Chloro-8-methoxyquinoline-3-carboxylic acid ethyl ester 
• 1443361-44-1 8-methoxy-1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1443361-55-4 1-([1,1′-biphenyl]-4-ylmethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1443361-20-3 ethyl 8-methoxy-1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1443361-33-8 ethyl 1-([1,1′-biphenyl]-4-ylmethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1314230-69-7 1,4-dihydro-8-methoxy-4-oxo-1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-3-quinolinecarboxamide 
• 35975-69-0 8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 121996-74-5 ethyl 1,4-dihydro-1-(2,4-dinitrophenyl)-8-methoxy-4-oxo-3-quinolinecarboxylate 

Relevant articles and documents

Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay

Type-1 ryanodine receptor (RyR1) is a calcium-release channel localized on sarcoplasmic reticulum (SR) of the skeletal muscle, and mediates muscle contraction by releasing Ca2+ from the SR. Genetic mutations of RyR1 are associated with skeletal muscle diseases such as malignant hyperthermia and central core diseases, in which over-activation of RyR1 causes leakage of Ca2+ from the SR. We recently developed an efficient high-throughput screening system based on the measurement of Ca2+ in endoplasmic reticulum, and used it to identify oxolinic acid (1) as a novel RyR1 channel inhibitor. Here, we designed and synthesized a series of quinolone derivatives based on 1 as a lead compound. Derivatives bearing a long alkyl chain at the nitrogen atom of the quinolone ring and having a suitable substituent at the 7-position of quinolone exhibited potent RyR1 channel-inhibitory activity. Among the synthesized compounds, 14h showed more potent activity than dantrolene, a known RyR1 inhibitor, and exhibited high RyR1 selectivity over RyR2 and RyR3. These compounds may be promising leads for clinically applicable RyR1 channel inhibitors.

Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2

The cannabinoid receptor type 2 (CB2) is part of the endocannabinoid system and has gained growing attention in recent years because of its important role in neuroinflammatory/neurodegenerative diseases. Recently, we reported on a carbon-11 labeled 4-oxo-

Regiocontrolled Nitration of 4-Quinolones at Ambient Conditions

Regiocontrolled nitration of 4-quinolone, the highly privileged scaffold, has been developed at ambient conditions. The nitro group can selectively be introduced at diverse positions simply by tuning the reactivity of the moiety. Discrimination is being achieved through the selective functionalization of the free N-H group. The functional group has been screened theoretically with the help of Fukui function and local softness calculation. Theoretical predictions are synchronized well with the experimental findings. Finally, this nitration technique allows quick access to the structurally diverse 4-quinolones.