71089-74-2

Basic information

• Product Name: 1,4,8,11-Tetrakis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane
• Synonyms: 1,4,8,11-Tetrakis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane;1,4,8,11-tetratosyl-1,4,8,11-tetraazacyclotetradecane;1,4,8,11-tetrakis-(4-methylphenyl)sulfonyl-1,4,8,11-tetrazacyclotetradecane
• CAS NO: 71089-74-2
• Molecular Formula: C₃₈H₄₈N₄O₈S₄
• Molecular Weight: 817.07
• Mol File: 71089-74-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 916.9 °C at 760 mmHg
• Flash Point: 508.3 °C
• Appearance: /
• Density: 1.303
• Vapor Pressure: 1.42E-34mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1,4,8,11-Tetrakis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,8,11-Tetrakis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane(71089-74-2)
• EPA Substance Registry System: 1,4,8,11-Tetrakis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane(71089-74-2)

Safety Data

• Hazardous Substances Data: 71089-74-2(Hazardous Substances Data)

Usage

General Description

1,4,8,11-Tetrakis[(4-methylphenyl)sulfonyl]-1,4,8,11-tetraazacyclotetradecane, also known as "TMTAA", is a macrocyclic compound that belongs to the class of sulfonyl-tetrazamacrocycles. This chemical is often used as a ligand in coordination chemistry and as a building block in the synthesis of coordination polymers and metal-organic frameworks. TMTAA has a unique structure with four nitrogen atoms and four bulky sulfonyl groups, making it an effective chelating agent for various metal ions. Its complex structure and coordination abilities make it a versatile molecule with potential applications in catalysis, sensing, and material science. Furthermore, TMTAA has shown promising potential in the development of new materials for gas storage and separation, as well as in the design of new catalysts for organic transformations.

InChI:InChI=1/C38H48N4O8S4/c1-31-7-15-35(16-8-31)51(43,44)39-23-5-24-41(53(47,48)37-19-11-33(3)12-20-37)29-30-42(54(49,50)38-21-13-34(4)14-22-38)26-6-25-40(28-27-39)52(45,46)36-17-9-32(2)10-18-36/h7-22H,5-6,23-30H2,1-4H3

Upstream product

• 295-37-4 1,4,8,11-Tetraazacyclotetradecane 
• 98-59-9 p-toluenesulfonyl chloride 
• 4741-99-5 3,7-diazanonane-1,9-diamine 
• 36394-60-2 3,8-dioxo-4,7-diazadecanediamide 
• 477808-21-2 N-[2-(2-methoxycarbonyl-acetylamino)-ethyl]-malonamic acid methyl ester 
• 10563-26-5 N,N'-bis(3-aminopropyl)-1,2-diamine 
• 111514-29-5 1,4,8,11-Tetrakis(toluene-p-sulphonyl)-1,4,8,11-tetraazaundecane 
• 109-64-8 1,3-dibromo-propane 
• 5469-66-9 propane-1,3-diol ditosylate 
• 6315-52-2 1,2-bis-tosyloxyethane 
• 74676-47-4 N,N',N'',N'''-tetratosyl-1,10-diamino-4,7-diazadecane 

Downstream Products

• 295-37-4 1,4,8,11-Tetraazacyclotetradecane 

Relevant articles and documents

Synthesis and structural characterization of N,N',N'',N'''-tetrasubstituted cyclams

[Figure not available: see fulltext.] Tetrasubstituted cyclams of formulae (3,5-Me2C6H3CH2)4Cyclam and (4-MeC6H4SO2)4Cyclam were synthesized by reaction of

ARENE CONNECTED POLYAMINE MACRORING DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

Abstract: The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.

Synthesis and characterization of various unsubstituted and mono-N-substituted tetraazamacrocycles

Syntheses of tetraazamacrocycles have been carried out by using p-toluenesulfonyl chloride as protective group.The and were also obtained by the template synthesis.Mono-N-functionalization of tetraazamacrocycles was accomplished by reaction of a fivefold excess of the free macrocycles with 1 equivalent of a suitable alkylating or arylating reagent.The key point of the synthesis lies in the use of an excess of the macrocycle over the substituting reactants to reduce the formation of polysubstituted derivatives, and in the easy separation of the excess of unreacted macrocycle.All the products were characterized on the basis of spectral studies (1H and 13C NMR, including 2D NMR and NOE difference studies) and mass spectrometry.Key words: tetraazamacrocycles, improved synthesis, protective group, N-tosylation, template synthesis, NOE difference spectroscopy.