710947-12-9

Basic information

• Product Name: 4-[4-(4-methoxy-phenyl)-5-(6-methyl-pyridin-2-yl)-[1,2,3]triazol-2-yl]-benzonitrile
• Synonyms: 4-[4-(4-methoxy-phenyl)-5-(6-methyl-pyridin-2-yl)-[1,2,3]triazol-2-yl]-benzonitrile
• CAS NO: 710947-12-9
• Molecular Weight: 367.41
• Mol File: 710947-12-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[4-(4-methoxy-phenyl)-5-(6-methyl-pyridin-2-yl)-[1,2,3]triazol-2-yl]-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(4-methoxy-phenyl)-5-(6-methyl-pyridin-2-yl)-[1,2,3]triazol-2-yl]-benzonitrile(710947-12-9)
• EPA Substance Registry System: 4-[4-(4-methoxy-phenyl)-5-(6-methyl-pyridin-2-yl)-[1,2,3]triazol-2-yl]-benzonitrile(710947-12-9)

Safety Data

• Hazardous Substances Data: 710947-12-9(Hazardous Substances Data)

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 428817-45-2 2-[5-(4-Methoxyphenyl)-2H-[1,2,3]triazol-4-yl]-6-methylpyridine 
• 5315-25-3 2-bromo-6-methylpyridine 
• 768-60-5 4-methoxyphenylacetylen 

Relevant articles and documents

Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor β1 type 1 receptor

A series of 2-pyridinyl-[1,2,3]triazoles have been synthesized and evaluated for their ALK5 inhibitory activity in the luciferase reporter assays. Compound 8d showed significant ALK5 inhibition (SBE-luciferase activity, 25%; p3TP-luciferase activity, 17%) at a concentration of 5μM that is comparable to that of SB-431542 (SBE-luciferase activity, 21%; p3TP-luciferase activity, 12%), but weak p38α MAP kinase inhibition (13%) at a concentration of 10μM that is much lower than that of SB-431542 (54%).