71208-55-4 Usage
Description
Diethyl (6-chloro-9H-carbazol-2-yl)methylmalonate is a chemical compound that serves as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It is characterized by its unique molecular structure, which includes a 6-chloro-9H-carbazol-2-yl group attached to a malonate moiety through a methylene bridge. diethyl (6-chloro-9H-carbazol-2-yl)methylmalonate plays a crucial role in the development of new drugs and materials.
Uses
Used in Pharmaceutical Industry:
Diethyl (6-chloro-9H-carbazol-2-yl)methylmalonate is used as a key intermediate in the synthesis of Carprofen (C184350), a non-steroidal anti-inflammatory drug (NSAID). It is particularly utilized for the relief of arthritic symptoms in dogs, such as joint pain or post-operative inflammation. Carprofen is also used to alleviate pain and inflammation associated with osteoarthritis, hip dysplasia, and other joint issues in animals.
Used in Organic Synthesis:
Diethyl (6-chloro-9H-carbazol-2-yl)methylmalonate is employed as a versatile building block in the synthesis of various organic compounds and materials. Its unique structure allows for further functionalization and modification, making it a valuable component in the development of new molecules with potential applications in various fields, such as medicine, materials science, and chemical research.
Check Digit Verification of cas no
The CAS Registry Mumber 71208-55-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,2,0 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 71208-55:
(7*7)+(6*1)+(5*2)+(4*0)+(3*8)+(2*5)+(1*5)=104
104 % 10 = 4
So 71208-55-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H20ClNO4/c1-3-25-19(23)16(20(24)26-4-2)9-12-5-7-14-15-11-13(21)6-8-17(15)22-18(14)10-12/h5-8,10-11,16,22H,3-4,9H2,1-2H3
71208-55-4Relevant articles and documents
Isolation and identification of an unusual impurity in an intermediate of Rimadyl (carprofen)
Tucker, John L.,DeVries, Keith M.,Hammen, Philip D.,Rose, Peter R.,Raymer, Brian K.,Rescek, Diane
, p. 1681 - 1688 (2007/10/03)
The isolation and identification of an unknown process related impurity in a key intermediate of Rimadyl (carprofen) is described. The structure of the unknown was evaluated by NMR spectral analysis and eventually confirmed by single crystal X-Ray. A re-slurry in warm acetic acid was found to reduce the level of the unknown to an acceptable level.
Process of making 6-chloro-α-methyl-carbazole-2-acetic acid
-
, (2008/06/13)
The aromatization of (6-chloro-1,2,3,4-tetrahydro-2-carbazolyl)-methyl-malonic acid dialkyl ester, utilizing chlorine and subsequent conversion of the resulting product to 6-chloro-α-methyl-carbazole-2-acetic acid by hydrolysis and decarboxylation are described.