71254-67-6

Basic information

• Product Name: 7-METHOXY-1,1-DIOXO-1,4-DIHYDRO-2H-1LAMBDA6-BENZO[1,2,4]THIADIAZIN-3-ONE
• Synonyms: 7-METHOXY-1,1-DIOXO-1,4-DIHYDRO-2H-1LAMBDA6-BENZO[1,2,4]THIADIAZIN-3-ONE
• CAS NO: 71254-67-6
• Molecular Formula: C₈H₈N₂O₄S
• Molecular Weight: 228.22512
• Mol File: 71254-67-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Density: 1.468g/cm³
• Refractive Index: 1.582
• CAS DataBase Reference: 7-METHOXY-1,1-DIOXO-1,4-DIHYDRO-2H-1LAMBDA6-BENZO[1,2,4]THIADIAZIN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-1,1-DIOXO-1,4-DIHYDRO-2H-1LAMBDA6-BENZO[1,2,4]THIADIAZIN-3-ONE(71254-67-6)
• EPA Substance Registry System: 7-METHOXY-1,1-DIOXO-1,4-DIHYDRO-2H-1LAMBDA6-BENZO[1,2,4]THIADIAZIN-3-ONE(71254-67-6)

Safety Data

• Hazardous Substances Data: 71254-67-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N2O4S/c1-14-5-2-3-6-7(4-5)15(12,13)10-8(11)9-6/h2-4H,1H3,(H2,9,10,11)

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 104-94-9 4-methoxy-aniline 
• 79-24-3 Nitroethane 
• 75-52-5 nitromethane 

Downstream Products

• 1432503-63-3 C₁₇H₁₅F₃N₂O₅S 
• 1432503-62-2 C₁₇H₁₆BrFN₂O₅S 
• 1432503-61-1 methyl 2-(7-methoxy-1,1-dioxo-2-(2,4,5-trifluorobenzyl)-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate 
• 1432503-59-7 methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-methoxy-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate 
• 477932-78-8 N-(4-methoxy-2-sulfamoylphenyl)malonamic acid ethyl ester 
• 6451-50-9 2-amino-5-methoxybenzenesulphonamide 

Relevant articles and documents

"a Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII

The sweeteners saccharin (SAC) and acesulfame K (ACE) recently entered the topic of anticancer human carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, as they showed to selectively inhibit the tumor-associated CAs IX/XII over ubiquitous CAs. A drug design s

FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY

A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.

BENZOTHIADIAZINE COMPOUNDS

The invention is directed to substituted benzothiadiazine derivatives. Specifically, the invention is directed to compounds according to Formula (I):wherein R, R1, R2, R3, R4 and R5 are as defined herein. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, autoimmune diseases, infections, atherosclerosis, and ischemia-reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.