71255-10-2Relevant articles and documents
Catalyzed Metalation Applied to 2-Methoxypyridine
Trecourt, F.,Mallet, M.,Marsais, F.,Queguiner, G.
, p. 1367 - 1371 (1988)
Directed ortho lithiation of 2-methoxypyridine (1) has been regioselectively achieved at position 3 by using methyllithium catalyzed by a small amount of diisopropylamine.This metalation methodology, called "catalyzed metalation", gave good results whereas other metalation routes failed.This allowed the convenient synthesis of various 3-substituted 2-methoxypyridines of general interest.