71258-18-9 Usage
Description
1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride is a piperidine derivative characterized by its white to beige powder form. It is a chemical compound with a specific molecular structure that has been identified for its potential applications in various fields, particularly as a calcium channel blocker.
Uses
1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride is used as a calcium channel blocker for its ability to regulate the flow of calcium ions through cellular membranes. This property makes it a valuable compound in the pharmaceutical industry for the development of medications targeting conditions related to calcium channel dysregulation.
Used in Pharmaceutical Industry:
1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride is used as an active pharmaceutical ingredient for the development of drugs aimed at treating cardiovascular diseases and other conditions where calcium channel modulation is beneficial. Its role as a calcium channel blocker helps in managing the contraction and relaxation of heart muscles and blood vessel dilation, which can be crucial in treating hypertension, angina, and certain arrhythmias.
Additionally, due to its chemical properties and potential applications, 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride may also be utilized in other industries for various purposes, such as in chemical research or as an intermediate in the synthesis of other compounds with specific therapeutic or industrial applications. However, the primary use highlighted in the provided materials is its application as a calcium channel blocker in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 71258-18-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,2,5 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 71258-18:
(7*7)+(6*1)+(5*2)+(4*5)+(3*8)+(2*1)+(1*8)=119
119 % 10 = 9
So 71258-18-9 is a valid CAS Registry Number.
InChI:InChI=1/C19H20N2/c20-16-19(18-9-5-2-6-10-18)11-13-21(14-12-19)15-17-7-3-1-4-8-17/h1-10H,11-15H2/p+1
71258-18-9Relevant articles and documents
Preparation method of 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride
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Paragraph 0007; 0023; 0038-0048; 0063-0074; 0088-0098, (2021/05/29)
The invention relates to the technical field of organic synthesis, in particular to a preparation method of 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride. The preparation method disclosed by the invention comprises the following steps of: (1) preparing benzyl diethanolamine by taking benzyl chloride and diethanolamine as raw materials; (2) preparing benzyl dichloroethylamine hydrochloride by taking benzyl diethanolamine and thionyl chloride as raw materials; and (3) preparing the 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride by taking the benzyl dichloroethylamine hydrochloride and the benzyl cyanide as raw materials. The preparation method disclosed by the invention is simple in process and suitable for industrial production, the HPLC content of the finally obtained 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride is greater than or equal to 98.0%, the total yield (based on diethanolamine) is greater than or equal to 89%, and the 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride has a very good market prospect.
HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES
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, (2008/06/13)
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Impurities in drugs II: meperidine and its formulations.
McErlane et al.
, p. 958,960 (2007/10/06)
Three lots of meperidine hydrochloride, seven lots of meperidine tablets, and 41 lots of meperidine injectables were examined for impurities by TLC. Impurities found were ethyl 1-benzyl-4-phenyl-4-piperidinecarboxylate, methyl-4-piperidinecarboxylate, ethyl-4-phenyl-4-piperidinecarboxylate, and three unidentified compounds. Not all impurities were found in every lot of drug investigated, and none of the impurities exceeded a concentration of 1% of the meperidine present.