7126-50-3

Basic information

• Product Name: ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE
• Synonyms: ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE;1H-Pyrrole-2-carboxylic acid, 5-forMyl-, ethyl ester
• CAS NO: 7126-50-3
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16196
• Product Categories: CHIRAL CHEMICALS
• Mol File: 7126-50-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 321.7°C at 760 mmHg
• Flash Point: 148.3°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 0.000294mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.45±0.50(Predicted)
• CAS DataBase Reference: ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE(7126-50-3)
• EPA Substance Registry System: ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE(7126-50-3)

Safety Data

• Hazardous Substances Data: 7126-50-3(Hazardous Substances Data)

Usage

General Description

Ethyl 5-formyl-1H-pyrrole-2-carboxylate is a chemical compound with the molecular formula C9H9NO3. It is a derivative of pyrrole, a five-membered aromatic ring containing one nitrogen atom. ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE is an ester, containing an ethyl group, a formyl group, and a carboxylate group. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds due to its versatile reactivity and ability to participate in a variety of chemical reactions.ETHYL 5-FORMYL-1H-PYRROLE-2-CARBOXYLATE is mainly used in the synthesis of pharmaceutical products.

InChI:InChI=1/C8H9NO3/c1-2-12-8(11)7-4-3-6(5-10)9-7/h3-5,9H,2H2,1H3

Upstream product

• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 7126-51-4 5-formyl-1H-pyrrole-2-carboxylic acid 
• 1356016-44-8 ethyl pyrrolo[2,1-f][1,2,4]triazine-7-carboxylate 
• 1356016-43-7 4-chloro-pyrrolo[2,1-f][1,2,4]triazine-7-carboxylic acid ethyl ester 
• 1263420-05-8 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylic acid 
• 1263420-04-7 ethyl 3-cyano-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-7-carboxylate 
• 1263420-06-9 tert-butyl 3-carbamoyl-4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazin-7-ylcarbamate 
• 1263419-08-4 4-(2-methylcyclohexylamino)-7-(2,2,2-trifluoroacetamido)pyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263419-68-6 4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-3,7-dicarboxamide 
• 952569-58-3 5-(ethoxycarbonyl)-1H-pyrrole-2-carboxylic acid 

Relevant articles and documents

Identification of azepinone fused tetracyclic heterocycles as new chemotypes with protein kinase inhibitory activities

The design and synthesis of small tetracyclic heterocycles which bear two new regioisomeric 2-carboxyethyl-1H-pyrrole-annulated indoloazepinone scaffolds is described. An azepinone motif, which is inherent in the structures of many well studied protein kinase inhibitors, serves as prominent structural feature of the new compounds. Concise access to the new regioisomeric tetracyclic derivatives was accomplished through amide coupling of appropriate pyrrole and indole precursors followed by an intramolecular Heck coupling reaction of the intermediate amide conjugates. Preliminary evaluation of newly synthesized tetracyclic molecules against a panel of protein kinases indicated their inhibitory activities and revealed promising selectivity profiles. The new compounds displayed no significant antiproliferative activity against MCF-7 cancer cells. Interestingly, derivative 19a exhibited selective TAK1 kinase inhibitory activity and figures as a promising chemotype for the discovery of new TAK1 inhibitors.

5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors

The present invention relates to 5-sulfonamido substituted indolinones that modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

SUBSTITUTED PYRAZOLE ANGIOTENSIN II ANTAGONISTS

Substituted pyrazoles such as STR1 and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.