71270-60-5

Basic information

• Product Name: N-(3-chloro-4-fluorophenyl)methanesulfonamide
• Synonyms: N-(3-chloro-4-fluorophenyl)methanesulfonamide
• CAS NO: 71270-60-5
• Molecular Formula: C₇H₇ClFNO₂S
• Molecular Weight: 223.6523832
• Mol File: 71270-60-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-chloro-4-fluorophenyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chloro-4-fluorophenyl)methanesulfonamide(71270-60-5)
• EPA Substance Registry System: N-(3-chloro-4-fluorophenyl)methanesulfonamide(71270-60-5)

Safety Data

• Hazardous Substances Data: 71270-60-5(Hazardous Substances Data)

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 71270-44-5 2-[(3-Chloro-4-fluoro-phenyl)-methanesulfonyl-amino]-thioacetamide 

Relevant articles and documents

Soft-Hard Acid/Base-Controlled, Oxidative, N-Selective Arylation of Sulfonanilides via a Nitrenium Ion

In iodine(III)-catalyzed, dehydrogenative arylations of sulfonanilides, the functionalization of C-C bonds is preferred over the functionalization of C-N bonds. Herein, an unprecedented N-selective arylation of sulfonanilides using soft-hard acid-base (SHAB) control by a nitrenium ion over a carbenium ion is reported. Treatment of sulfonanilides with iodine(III) led to the formation of nitrenium ions (soft), which preferentially react with biphenyls (soft) over bimesityl (hard) to generate C-N bonds. The iodine(III) was generated in situ by using PhI and mCPBA at room temperature.