7134-41-0

Basic information

• Product Name: 4-mercaptobenzenesulfonic acid
• Synonyms: 4-mercaptobenzenesulfonic acid;Nsc127168;4-Mercaptobenzenesulphonicacid;p-Mercaptobenzenesulfonic acid
• CAS NO: 7134-41-0
• Molecular Formula: C₆H₆O₃S₂
• Molecular Weight: 190.24
• Mol File: 7134-41-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 251-253℃
• Appearance: /
• Density: 1.524g/cm³
• Refractive Index: 1.639
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-mercaptobenzenesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-mercaptobenzenesulfonic acid(7134-41-0)
• EPA Substance Registry System: 4-mercaptobenzenesulfonic acid(7134-41-0)

Safety Data

• Hazardous Substances Data: 7134-41-0(Hazardous Substances Data)

Usage

General Description

4-Mercaptobenzenesulfonic acid is a compound consisting of a benzene ring with a sulfonic acid group and a thiol group attached to it. It is commonly used as a reagent in organic synthesis and as a corrosion inhibitor in industrial applications. 4-mercaptobenzenesulfonic acid is a highly reactive and water-soluble molecule, making it useful for various chemical processes such as the synthesis of dyes, pharmaceuticals, and agrochemicals. Its thiol group allows it to form strong covalent bonds with metal surfaces, making it an effective corrosion inhibitor for metals such as iron and steel. Additionally, 4-mercaptobenzenesulfonic acid has potential applications in electrochemistry and as a catalyst in chemical reactions due to its ability to facilitate electron transfer processes.

InChI:InChI=1/C6H6O3S2/c7-11(8,9)6-3-1-5(10)2-4-6/h1-4,10H,(H,7,8,9)

Upstream product

• 111738-19-3 dianilinium 4,4'-dithiobis(benzenesulfonate) 
• 1161-11-1 4,4'-dithiobis(benzenesulphonic acid) 
• 121-57-3 4-aminobenzene sulfonic acid 
• 305-80-6 4-diazobenzenesulfonic acid 

Downstream Products

• 111738-22-8 Sodium 4-((5-Methyl-2-oxo-1,3-dioxol-4-yl)methylthio)benzenesulfonate 
• 1161-11-1 4,4'-dithiobis(benzenesulphonic acid) 
• 856066-53-0 C₆H₅Sb(SC₆H₄-4-SO₃H)2 
• 856161-88-1 4-HOC₆H₄Sb(SC₆H₄-4-SO₃H)2 
• 856161-93-8 4-H₂NC₆H₄Sb(SC₆H₄-4-SO₃H)2*HCl 
• 856156-36-0 4-CH₃CONHC₆H₄Sb(SC₆H₄-4-SO₃H)2 
• 872792-06-8 C₃H₅N₆C₆H₄Sb(SC₆H₄SO₃H)2 

Relevant articles and documents

2-Oxo-1,3-dioxoles as specific substrates for measurement of arylesterase activity

Various 4-arylthiomethyl-2-oxo-1,3-dioxole derivatives IIIa-o were synthesized. Their hydrolysis rates by arylesterase (EC 3.1.1.2) and cholinesterase (EC 3.1.1.8) in human serum were evaluated. Some of them were not hydrolyzed by cholinesterase, but were

Rate Constants and Equilibrium Constants for Thiol-Disulphide Interchange Reactions Involving Oxidized Glutathione

The rate of reduction of oxidized glutathione (GSSG) to glutathione (GSH) by thiolate (RS-) follows a Broensted relation in pKas of the conjugate thiols (RSH): βnuc ca. 0.5.This value is similar to that for reduction of Ellman's reagent: βnuc ca. 0.4 - 0.5.Analysis of a number of rate and equilibrium data, taken both from this work and from the literature, indicates that rate constants, k, for a range of thiolate-disulphide interchange reactions are correlated well by equations of the form log k = C + βnucpKanuc + βcpKac + βlgpKalg ( nuc = nucleophile, c = central, and lg = leaving group sulfur): eq 36 - 38 give representative values of the Broensted coefficients.The values of these Bronsted coefficients are not sharply defined by the available experimental data, although eq 36 - 38 provide useful kinetic models for rates of thiolate-disulfide interchange reactions.The uncertainty in these parameters is such that their detailed mechanistic interpretation is not worthwhile, but their qualitative interpretation - that all three sulphur atoms experience a significant effective negative charge in the transition state, but that the charge is concentrated on the terminal sulfurs - is justified.Equilibrium constants for reduction of GSSG using α,ω-dithiols have been measured.The reducing potential of the dithiol is strongly influenced by the size of the cyclic disulfide formed on its oxidation: the most strongly reducing dithiols are those which can form six-membered cyclic disulfides.Separate equilibrium constants for thiolate anion-disulphide interchange (KS-) and for thiol-disufide interchange (KSH) have been estimated from literature data: KS- is roughly proportional to 2ΔpKa is the difference between the pKas of the two thiols involved in the interchange.The contributions of thiol pKa values to the observed equilibrium constants for reduction of GSSG with α,ω-dithiols appear to be much smaller than those ascribable to the influence of structure on intramolecular ring formation.These equilibrium and rate constants are helpful in choosing dithiols for use as antioxidants in solutions containing proteines: dithiothreitol (DTT), 1,3-dimercapto-2-propanol (DMP), and 2-mercaptoethanol have especially useful properties.