71347-59-6

Basic information

• Product Name: 1-(6-(4-FLUOROPHENYL)-1,2,4-TRIAZIN-3-YL)HYDRAZINE
• Synonyms: 1-(6-(4-FLUOROPHENYL)-1,2,4-TRIAZIN-3-YL)HYDRAZINE;6-(4-fluorophenyl)-3-hydrazinyl-1,2,4-triazine
• CAS NO: 71347-59-6
• Molecular Formula: C₉H₈FN₅
• Molecular Weight: 205.1917232
• Mol File: 71347-59-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 433.2 °C at 760 mmHg
• Flash Point: 215.8 °C
• Appearance: /
• Density: 1.412 g/cm³
• Vapor Pressure: 1.04E-07mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.23±0.20(Predicted)
• CAS DataBase Reference: 1-(6-(4-FLUOROPHENYL)-1,2,4-TRIAZIN-3-YL)HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-(4-FLUOROPHENYL)-1,2,4-TRIAZIN-3-YL)HYDRAZINE(71347-59-6)
• EPA Substance Registry System: 1-(6-(4-FLUOROPHENYL)-1,2,4-TRIAZIN-3-YL)HYDRAZINE(71347-59-6)

Safety Data

• Hazardous Substances Data: 71347-59-6(Hazardous Substances Data)

Usage

General Description

1-(6-(4-FLUOROPHENYL)-1,2,4-TRIAZIN-3-YL)HYDRAZINE is a chemical compound with a complex structure consisting of a hydrazine molecule attached to a 1,2,4-triazin-3-yl group, which in turn is connected to a 4-fluorophenyl group. 1-(6-(4-FLUOROPHENYL)-1,2,4-TRIAZIN-3-YL)HYDRAZINE is of interest in medicinal chemistry due to its potential pharmacological properties. It may have applications in the development of new drugs or as a building block for synthesizing other biologically active molecules. The specific properties and potential uses of this chemical may vary depending on its exact structure and how it is formulated and used.

InChI:InChI=1/C9H8FN5/c10-7-3-1-6(2-4-7)8-5-12-9(13-11)15-14-8/h1-5H,11H2,(H,12,13,15)

Downstream Products

• 71347-60-9 6-(4-fluorophenyl)-3-methyl[1,2,4]triazolo[4,3-b][1,2,4]triazine 
• 1399857-76-1 6-(4-fluorophenyl)-3-((1H-pyrazolo[3,4-d]pyrimidin-4-ylthio)methyl)[1,2,4]triazolo[4,3-b][1,2,4]triazine 
• 1399857-78-3 6-((6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline 
• 1399857-77-2 3-(((6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)thio)-5-(methylamino)isothiazole-4-carboxamide 
• 1399857-75-0 6-(4-fluorophenyl)-3-((thieno[3,2-b]pyridin-7-yloxy)methyl)[1,2,4]triazolo[4,3-b][1,2,4]triazine 
• 1399857-74-9 6-(4-fluorophenyl)-3-((pyridin-3-yloxy)methyl)[1,2,4]triazolo[4,3-b][1,2,4]triazine 
• 1399857-73-8 1-((6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)pyridin-4(1H)-one 
• 1399857-72-7 2-chloro-4-((6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)phenol 
• 1399857-71-6 3-(4-fluorobenzyl)-6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b][1,2,4]triazine 
• 1399857-70-5 6-(4-fluorophenyl)-3-(4-methoxybenzyl)[1,2,4]triazolo[4,3-b][1,2,4]triazine 
• 71347-57-4 6-(4-fluoro-phenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazine 

Relevant articles and documents

Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor

c-Met/HGF overexpression has been detected in many human malignancies including tumors which are resistant to anticancer therapy. Disrupting the aberrant c-Met/HGF axis has enjoyed significant progress in both preclinical and clinical antitumor campaign. To eliminate the OCH2-related metabolic deficiency of our previously reported triazolotriazine 2, we synthesized a series of CH2-/CF2-linked triazolotriazines and assessed their c-Met activities, leading to the highly potent compound 23 with IC50 values of 0.24 nM of enzymatic activity in c-Met and 0.85 nM of cellular activity in EBC-1 cancer cell line, as well as with complete tumor regression in EBC-1 xenograft mice model at dose of 25 mg/kg via oral administration. Based on its potent anti-proliferative activities and favorable pharmacokinetic properties, 23 has been selected as a drug candidate for preclinical investigation.

TRIAZOLOTRIAZINES AS KINASE INHIBITORS

-