71447-49-9

Basic information

• Product Name: Gonadorelin acetate
• Synonyms: LUTEINIZING HORMONE RELEASING HORMONE (HUMAN) (PORCINE, RAT) 2ACOH 4H2O;GONADOTROPIN-RELEASING HORMONE (PORCINE, RAT) 2ACOH 4H2O;GNRH (PORCINE, RAT) 2ACOH 4H2O;LH-RH (HUMAN) (PORCINE, RAT) 2ACOH 4H2O;LH-RH HUMAN DIACETATE SALT;gonadorelindiacetate;lhrhdiacetate;luteinizinghormone-releasinghormone,diacetate(salt)
• CAS NO: 71447-49-9
• Molecular Formula: C59H83N17O17
• Molecular Weight: 1302.39
• EINECS: 232-895-0
• Product Categories: Amino Acid Derivatives;Peptide;API;peptides
• Mol File: 71447-49-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: −20°C
• Solubility: H2O: 25 mg/mL, clear, faintly yellow
• CAS DataBase Reference: Gonadorelin acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Gonadorelin acetate(71447-49-9)
• EPA Substance Registry System: Gonadorelin acetate(71447-49-9)

Safety Data

• Hazard Codes: T
• Statements: 60
• Safety Statements: 53-45
• WGK Germany: 3
• RTECS: OK6470000
• F: 10-21
• Hazardous Substances Data: 71447-49-9(Hazardous Substances Data)

Usage

Description

Gonadorelin acetate, also known as Luteinizing hormone-releasing hormone (LHRH) human acetate salt, is a synthetically produced decapeptide that mimics the action of the naturally occurring gonadotropin-releasing hormone (GnRH). It plays a crucial role in the regulation of the reproductive system by stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. Gonadorelin acetate is widely used in various medical and research applications due to its ability to control and manipulate the reproductive cycle.

Uses

Used in Reproductive Medicine:
Gonadorelin acetate is used as a therapeutic agent for the synchronization of ovulations, which is essential in assisted reproductive technologies such as in vitro fertilization (IVF) and controlled ovarian stimulation (COS). It helps in aligning the timing of egg maturation and ovulation, thereby increasing the chances of successful fertilization.
Used in Research and Diagnostics:
Gonadorelin acetate is used as a research tool for the pre-absorption of anti-GnRH antibodies in staining procedures. This application aids in the accurate detection and quantification of GnRH receptors in various tissues, which is crucial for understanding the role of GnRH in the reproductive system and its potential as a target for therapeutic intervention.
Used in Endocrinology:
Gonadorelin acetate is used as a diagnostic agent to study pituitary sensitivity to GnRH in the presence of endocrine-disrupting compounds. This application helps in evaluating the functionality of the hypothalamic-pituitary-gonadal (HPG) axis and identifying potential disruptions caused by environmental factors or other pathological conditions.

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.