7147-66-2

Basic information

• Product Name: 1,3-bis(2-benzimidazole)propane
• Synonyms: 1,3-bis(2-benzimidazole)propane;1,3-Bis(1H-benzo[d]imidazol-2-yl)propane
• CAS NO: 7147-66-2
• Molecular Formula: C₁₇H₁₆N₄
• Molecular Weight: 276.33574
• Mol File: 7147-66-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,3-bis(2-benzimidazole)propane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(2-benzimidazole)propane(7147-66-2)
• EPA Substance Registry System: 1,3-bis(2-benzimidazole)propane(7147-66-2)

Safety Data

• Hazardous Substances Data: 7147-66-2(Hazardous Substances Data)

Usage

Description

1,3-bis(2-benzimidazole)propane, also known as BBP, is a chemical compound belonging to the bis(benzimidazole) family, characterized by high thermal and chemical stability. It is recognized for its potential applications in flame retardants, corrosion inhibitors, and as a ligand for metal coordination complexes. BBP also demonstrates promising properties in the medical field, including anti-tumor and anti-inflammatory effects, and is considered a candidate for the development of advanced materials and polymers.

Uses

Used in Flame Retardants:
1,3-bis(2-benzimidazole)propane is used as a flame retardant for enhancing the fire resistance of various materials, providing safety and protection against fire hazards.
Used in Corrosion Inhibitors:
BBP serves as a corrosion inhibitor, preventing the degradation of metals and materials, thereby extending their service life and maintaining structural integrity.
Used as a Ligand for Metal Coordination Complexes:
1,3-bis(2-benzimidazole)propane is utilized as a ligand in the formation of metal coordination complexes, which have potential applications in various fields, including catalysis and sensing.
Used in Medical Applications:
In the medical field, BBP is used for its anti-tumor and anti-inflammatory properties, offering potential therapeutic benefits in the treatment of various diseases and conditions.
Used in Advanced Materials and Polymers Development:
Due to its unique molecular structure and properties, 1,3-bis(2-benzimidazole)propane is employed in the development of advanced materials and polymers, contributing to the creation of innovative products with enhanced performance characteristics.
Further research is necessary to fully explore and understand the potential uses and benefits of 1,3-bis(2-benzimidazole)propane across different industries and applications.

Upstream product

• 111-30-8 Glutaraldehyde 
• 95-54-5 1,2-diamino-benzene 
• 1119-40-0 Dimethyl glutarate 
• 110-94-1 1,5-pentanedioic acid 

Downstream Products

• 1431139-12-6 1-(pyridin-2-ylmethyl)-2-(3-(1-(pyridin-2-ylmethyl)benzimidazol-2-yl)propyl)benzimidazole 
• 1361000-22-7 C₂₃H₂₆N₄O₂ 

Relevant articles and documents

Bisbenzimidazole Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Biological Evaluation and Pharmacophore Analysis

In an attempt to design and synthesize a potent class of antimicrobials, 1,2-phenylenediamine derivatives were reacted with various aliphatic and heteroaliphatic dicarboxylic acids to generate a small library of 26 head-to-head bisbenzimidazole compounds (16 – 42) using the polyphosphoric acid method. These compounds were screened for their antibacterial activity and their antifungal activity. Compound 25 showed maximum potency against both Gram-positive and Gram-negative bacterial strains with minimum inhibitory concentration (MIC) values in the range of 7.81 – 31.25 μg/mL. In particular, it showed the maximum MIC values of 7.81 μg/mL against Gram-negative bacteria, which was four-fold more active than the standard drug ampicillin (MIC = 32.25 μg/mL). Compound 19 was found to be the most active against S. aureus with a MIC value of 3.90 μg/mL, whereas the remaining compounds showed only low-to-moderate activity. Furthermore, all compounds exhibited low activity against all fungal strains in comparison to the standard drug fluconazole. I addition, pharmacophore hypotheses were generated to analyze structure–activity relationships between the molecular structures and antimicrobial activities on E. coli. This pharmacophore model can be useful in order to design new antimicrobial drugs. It can be suggested that the substitution of a phenyl ring at the 5/6 and 5′/6′ positions in symmetric bisbenzimidazole derivatives produces compounds with promising antimicrobial activity.

CuO nano-particles supported on silica, a new catalyst for facile synthesis of benzimidazoles, benzothiazoles and benzoxazoles

A facile synthetic route for benzimidazoles, benzothiazoles and benzoxazoles comprising the reaction of corresponding o-phenylenediamine, o-aminothiophenol and o-aminophenol with various aldehydes using silica supported nano-copper (II) oxide as a catalyst has been described. The catalyst exhibited clean reaction profile with excellent yields in a short reaction time. The catalyst can be recycled effectively after use.

Synthesis and anti-HIV activity of [ddN]-[ddN] dimers and benzimidazole nucleoside dimers

In an attempt to combine the HIV-inhibitory capacity of different 2′,3′-dideoxynucleoside (ddN) analogs, we have designed and synthesized several dimers of [AZT]-[AZT] and [AZT]-[d4T]. In addition, we also synthesized the dimers of 1-(1H-benzimidazol-1-yl