7148-02-9

Basic information

• Product Name: ethyl 3-hydroxy-3,4,4-trimethylpentanoate
• CAS NO: 7148-02-9
• Molecular Formula: C₁₀H₂₀O₃
• Molecular Weight: 188.264
• Mol File: 7148-02-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 259.8°C at 760 mmHg
• Flash Point: 98.4°C
• Density: 0.966g/cm³
• Vapor Pressure: 0.00184mmHg at 25°C
• Refractive Index: 1.443
• CAS DataBase Reference: ethyl 3-hydroxy-3,4,4-trimethylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-hydroxy-3,4,4-trimethylpentanoate(7148-02-9)
• EPA Substance Registry System: ethyl 3-hydroxy-3,4,4-trimethylpentanoate(7148-02-9)

Safety Data

• Hazardous Substances Data: 7148-02-9(Hazardous Substances Data)

Upstream product

• 677-22-5 tert-butylmagnesium chloride 
• 141-78-6 ethyl acetate 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 105-36-2 ethyl bromoacetate 
• 105-39-5 chloroacetic acid ethyl ester 
• 60-29-7 diethyl ether 

Downstream Products

• 16466-40-3 3-Hydroxy-3,4,4-trimethyl-pentansaeure-(1) 
• 36976-65-5 ethyl (Z)-3-bromomethyl-4,4-dimethyl-2-pentenoate 
• 21016-48-8 (E)-3,4,4-trimethyl-1-pent-2-enoic acid ethyl ester 
• 36976-64-4 ethyl 4,4-dimethyl-3-methylenepentanoate 

Relevant articles and documents

Co-catalyzed reductive cyclization of azido and cyano substituted α,β-unsaturated esters with NaBH4: enantioselective synthesis of (R)-baclofen and (R)-rolipram

Sodium borohydride in combination with a catalytic amount of CoCl2 has been found to be an excellent catalytic system in reductive cyclizations of suitably substituted azido and cyano groups of α,β-unsaturated esters to afford γ and δ-lactams in high yields. The process has been demonstrated for the enantioselective synthesis of (R)-baclofen, (R)-rolipram, and (R)-4-fluorophenylpiperidinone, a key intermediate for (-)-paroxetine.

Base catalysis as an alternative explanation for an apparent deuterium solvent isotope effect in the photochemical reactions of α,β-unsaturated esters

-