71494-65-0

Basic information

• Product Name: 4-(4-Nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid
• Synonyms: 4-(4-Nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid;4-(4-NITRO-1,3-DIOXOISOINDOLIN-2-YL)BENZOIC ACID
• CAS NO: 71494-65-0
• Molecular Formula: C₁₅H₈N₂O₆
• Molecular Weight: 312.23382
• Mol File: 71494-65-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-Nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid(71494-65-0)
• EPA Substance Registry System: 4-(4-Nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid(71494-65-0)

Safety Data

• Hazardous Substances Data: 71494-65-0(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 641-70-3 3-nitrophthalic acid anhydride 
• 150-13-0 4-amino-benzoic acid 
• 603-11-2 3-nitrophthalic acid 

Downstream Products

• 71494-60-5 4-(3-azidophthalimidyl)-benzoic acid 

Relevant articles and documents

Method of inhibiting binding of nerve growth factor to p75 NTR receptor

The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTRcommon neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTRcomprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101and Phe86of nerve growth factor.

3- and 4-Azidophthalic acid derivatives

The compounds according to the invention have the formulae Ia or Ib STR1 in which Y is a divalent organic radical and Z is --NH2, --NH-alkyl having 1-4 C atoms, --OH, --COOH, --COCl, --O--CO--CH=CH2, STR2 --COO--CH=CH2 or