7151-76-0

Basic information

• Product Name: 4-(METHANESULFONYLAMINO)BENZOIC ACID
• Synonyms: RARECHEM AL BO 0801;P-(METHANESULFONAMIDO)BENZOIC ACID;4-[(METHYLSULFONYL)AMINO]BENZOIC ACID;4-(METHANESULFONYLAMINO)BENZOIC ACID;4-(Methanesulfonylamino)benzoic acid, min. 95 %;p-(Methanesulfonamide)benzoic Acid;4-(Methylsulphonamido)benzoic acid, N-(4-Carboxyphenyl)methanesulphonamide;4MB
• CAS NO: 7151-76-0
• Molecular Formula: C₈H₉NO₄S
• Molecular Weight: 215.23
• Mol File: 7151-76-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 408.8°C at 760 mmHg
• Flash Point: 201°C
• Appearance: /
• Density: 1.51g/cm³
• Vapor Pressure: 2.04E-07mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.17±0.10(Predicted)
• CAS DataBase Reference: 4-(METHANESULFONYLAMINO)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(METHANESULFONYLAMINO)BENZOIC ACID(7151-76-0)
• EPA Substance Registry System: 4-(METHANESULFONYLAMINO)BENZOIC ACID(7151-76-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 7151-76-0(Hazardous Substances Data)

Usage

General Description

4-(Methanesulfonylamino)benzoic acid is a chemical compound with the formula C8H9NO4S. It is a white crystalline solid that is commonly used as a pharmaceutical intermediate in the synthesis of other compounds. The compound has an aromatic benzene ring with a carboxylic acid functional group and a sulfonamide group. Its sulfonamide group makes it a potent inhibitor of carbonic anhydrase, which has potential therapeutic applications in the treatment of glaucoma and other conditions. Overall, 4-(methanesulfonylamino)benzoic acid is an important building block in the production of various pharmaceuticals and can be used as a research tool in drug development.

InChI:InChI=1/C8H9NO4S/c1-14(12,13)9-7-4-2-6(3-5-7)8(10)11/h2-5,9H,1H3,(H,10,11)

Upstream product

• 50790-28-8 methyl 4-(methanesulfonylamino)benzoate 
• 619-45-4 4-methoxycarbonyl aniline 
• 7143-01-3 Methanesulfonic anhydride 
• 7151-77-1 ethyl 4-(methylsulfonamido)benzoate 
• 124-63-0 methanesulfonyl chloride 
• 94-09-7 p-aminoethylbenzoate 
• 150-13-0 4-amino-benzoic acid 

Relevant articles and documents

Convenient synthesis of primary sulfonamides

An efficient protocol for a one-pot synthesis of mono-sulfonamides has been developed. It features utilization of excess of sulfonylating agent followed by base mediated recovery of the primary sulfonamide.

Compounds useful as reversible inhibitors of cysteine proteases

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.

Substituted benzene derivatives useful as neuraminidase inhibitors

A compound of the Formula (I): STR1 or pharmaceutically-suitable salts or prodrug forms thereof, wherein: n is 0-1; m is 0; p is 0-1; R1 is --CO2 H; R2 is selected from the group consisting of H, --OH, and --NH2 ; R3 is H; R4 is --C(O)NHR8 ; R5 is --NHC(R6)NH2 R6 is selected from the group consisting of =NH, =NOH, =NCN, =O, and =S; and R8 is selected from the group consisting of C1 -C4 linear or branched alkyl substituted with 0-3 halogens on each carbon.