71568-87-1

Basic information

• Product Name: Benzoic acid, 2-bromo-3,4-dimethoxy-
• CAS NO: 71568-87-1
• Molecular Formula: C9H9BrO4
• Molecular Weight: 261.072
• Mol File: 71568-87-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-bromo-3,4-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-bromo-3,4-dimethoxy-(71568-87-1)
• EPA Substance Registry System: Benzoic acid, 2-bromo-3,4-dimethoxy-(71568-87-1)

Safety Data

• Hazardous Substances Data: 71568-87-1(Hazardous Substances Data)

Upstream product

• 55171-60-3 2-bromo-3,4-dimethoxybenzylaldehyde 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 74-88-4 methyl iodide 
• 93-07-2 Veratric acid 
• 861614-43-9 5-acetylamino-2-bromo-3,4-dimethoxy-benzoic acid 
• 871892-91-0 3-acetylamino-4,5-dimethoxy-benzoic acid 
• 2973-58-2 2-bromoisovanillin 
• 621-59-0 isovanillin 
• 121-33-5 vanillin 
• 89984-23-6 2-amino-4-hydroxy-3-methoxy-benzaldehyde 
• 89984-24-7 2-bromo-4-hydroxy-3-methoxy-benzaldehyde 
• 2698-69-3 4-formyl-2-methoxy-3-nitrophenyl acetate 
• 881-68-5 vanillin acetate 
• 247579-47-1 (2-bromo-3,4-dimethoxy-phenyl)-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-methanone 

Downstream Products

• 121057-87-2 2-(2-Benzyloxy-phenoxy)-3,4-dimethoxy-benzoic acid benzyl ester 
• 121031-16-1 2-(2-Hydroxy-phenoxy)-3,4-dimethoxy-benzoic acid 
• 121031-20-7 benzyl 2-bromo-3,4-dimethoxybenzoate 
• 99425-65-7 3,4-dimethoxy-2-phenylsulfanyl-benzoic acid 
• 115049-80-4 2-bromo-3,4-dihydroxy-benzoic acid 
• 132185-19-4 methyl 2-bromo-3,4-dimetoxybenzoate 

Relevant articles and documents

Benzofuranone derivatives as well as preparation method and application thereof

The invention discloses benzofuranone derivatives as well as a preparation method and medical application thereof, and provides the benzofuranone derivatives, the preparation method thereof and an application of pharmaceutical composition containing the d

Synthesis of phthalideisoquinoline and protoberberine alkaloids and indolo[2,1-α]isoquinolines in a divergent route involving palladium(0)- catalyzed carbonylation

6,7,3',4'-Alkoxy-substituted 1-(2'-bromobenzoyl)-3,4-dihydroisoquinoline methiodides 17 were treated with sodium borohydride in methanol or acetic acid to give erythro-1-(2'-bromo-α-hydroxybenzyl)-2-methyl-1,2,3,4- tetrahydroisoquinolines 19. Treatment of 17 with lithium aluminum hydride in tetrahydrofuran gave the threo-isomer 20 in preference to the erythro 19. On the basis of studies on palladium(0)-catalyzed carbonylation of 2-bromo-3,4- dimethoxybenzyl alcohol to 6,7-dimethoxyphthalide, amino alcohol 19 or 20 was treated with a catalytic amount of palladium(II) acetate and triphenylphosphine in an atmosphere of carbon monoxide in the presence of chlorotrimethylsilane and potassium carbonate in boiling toluene to give the corresponding erythro- or threo-types of phthalideisoquinoline alkaloids 1 or 2, respectively. One-pot cyclization of the erythro-amino alcohols 19 was achieved by heating in N,N-dimethylformamide containing potassium carbonate to give 2,3,8,9- or 2,3,9,10-alkoxy-substituted 5,6-dihydroindolo[2,1- α]isoquinolines 3, which have a unique tetracyclic skeleton characteristic of dibenzopyrrocoline alkaloids. Similarly, palladium-(0)-catalyzed carbonylation of 1-(2'-bromobenzyl)tetrahydroisoquinolines 21 in the presence of excess potassium carbonate was found to give 8-oxoberbines 22, which on reduction with lithium aluminum hydride can be converted to protoberberine alkaloids 4.