7160-18-1

Basic information

• Product Name: N-(4-chlorophenyl)butanamide
• Synonyms: butanamide, N-(4-chlorophenyl)-; N-(4-Chlorophenyl)butanamide
• CAS NO: 7160-18-1
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.6614
• Mol File: 7160-18-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 354.9°C at 760 mmHg
• Flash Point: 168.4°C
• Density: 1.18g/cm³
• Vapor Pressure: 3.25E-05mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: N-(4-chlorophenyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)butanamide(7160-18-1)
• EPA Substance Registry System: N-(4-chlorophenyl)butanamide(7160-18-1)

Safety Data

• Hazardous Substances Data: 7160-18-1(Hazardous Substances Data)

Upstream product

• 1129-50-6 N-phenylbutyramide 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 104-12-1 p-chlorphenylisocyanate 
• 6622-16-8 benzyl (4-chlorophenyl)carbamate 
• 106-47-8 4-chloro-aniline 
• 141-75-3 butyryl chloride 
• 100-00-5 4-chlorobenzonitrile 
• 107-92-6 butyric acid 
• 106-31-0 butanoic acid anhydride 
• 67097-67-0 N-chloro-butyranilide 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 

Downstream Products

• 5441-81-6 N-butyl-N-(4-chlorophenyl)amine 

Relevant articles and documents

Practical one-pot amidation of N -Alloc-, N -Boc-, and N -Cbz protected amines under mild conditions

A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagents to produce the corresponding amides. Using this reaction protocol, a variety of N-Alloc-, N-Boc-, and N-Cbz-protected aliphatic amines and aryl amines were efficiently converted to amides with high yields. This method is highly effective for the synthesis of amides and offers a promising approach for facile amidation.

Organocatalytic and enantioselective [4+2] cyclization between hydroxymaleimides and: Ortho -hydroxyphenyl para -quinone methide-selective preparation of chiral hemiketals

A cinchona alkaloid squaramide promoted enantioselective [4+2] cyclization between hydroxymaleimides and ortho-hydroxyphenyl p-QMs has been disclosed, and a wide range of chiral hemiketals containing chromane and succinimide frameworks with two adjacent quaternary stereogenic centers have been prepared for the first time with excellent results (up to 99% yield, up to 99?:?1 dr, up to >99% ee) under mild conditions. This journal is

Direct hydrogenation of nitroaromatics and one-pot amidation with carboxylic acids over platinum nanowires

A novel ultrathin platinum nanowire with uniform length and a diameter of 1.5 nm was synthesized by acidic etching of FePt nanowire in methanol. This nanowire was characterized by high-resolution transmission electron microscopy (HRTEM). X-ray diffraction (XRD) data indicated that the main plane is (111). The ability of this nanowire to catalyze the heterogeneous hydrogenation of nitroaromatics to give the corresponding amines has been investigated. The catalyst showed satisfactory activity in various solvents under mild conditions and showed excellent stability. The catalytic performance was also evaluated in the one-pot reduction of nitroaromatics and amidation with carboxylic acids under a hydrogen atmosphere at 100°C. These methods for the hydrogenation of nitroaromatics and the direct amidation of nitroaromatics with carboxylic acids are simple, economical, and environmentally benign, and have practical advantages for the synthesis of amines and amides without the production of toxic byproducts.