716377-45-6

Basic information

• Product Name: 2-benzenesulfonylamino-5-[4-(3-nitro-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester
• Synonyms: 2-benzenesulfonylamino-5-[4-(3-nitro-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester
• CAS NO: 716377-45-6
• Molecular Weight: 532.618
• Mol File: 716377-45-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-benzenesulfonylamino-5-[4-(3-nitro-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzenesulfonylamino-5-[4-(3-nitro-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester(716377-45-6)
• EPA Substance Registry System: 2-benzenesulfonylamino-5-[4-(3-nitro-phenyl)-piperazin-1-yl]-5-oxo-pentanoic acid tert-butyl ester(716377-45-6)

Safety Data

• Hazardous Substances Data: 716377-45-6(Hazardous Substances Data)

Upstream product

• 402-67-5 3-fluoro-1-nitrobenzene 
• 54054-85-2 1-(3-nitrophenyl)piperazine 
• 189333-60-6 (S)-2-(benzenesulfonylamino)pentanedioic acid 1-tert.-butyl ester 

Downstream Products

• 716377-53-6 5-[4-(3-amino-phenyl)-piperazin-1-yl]-2-benzenesulfonylamino-5-oxo-pentanoic acid tert-butyl ester 

Relevant articles and documents

Discovery of a potent and selective αvβ3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model

A new series of phenylpiperazine-based derivatives with strong antagonistic activity for αvβ3 integrin were synthesized. Of these derivatives, the fluorine-substituted compound 8 showed strong inhibitory activity and high selectivity for αvβ 3 integrin receptor (IC50=0.055nM). In vivo evaluation of the antistenotic effects of 8 indicated that this compound significantly inhibits neointima formation in rat balloon injury model.