71649-83-7

Basic information

• Product Name: 2,2-Dimethylchroman-4-ol
• Synonyms: 2,2-Dimethylchroman-4-ol;2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-ol
• CAS NO: 71649-83-7
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.22766
• Mol File: 71649-83-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-Dimethylchroman-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethylchroman-4-ol(71649-83-7)
• EPA Substance Registry System: 2,2-Dimethylchroman-4-ol(71649-83-7)

Safety Data

• Hazardous Substances Data: 71649-83-7(Hazardous Substances Data)

Usage

General Description

2,2-Dimethylchroman-4-ol, also known as vitamin E acetate or tocopheryl acetate, is a synthetic variation of vitamin E commonly used in skincare products and dietary supplements. It is an antioxidant that helps protect cells from damage caused by free radicals and environmental stressors. Its chemical structure consists of a chroman ring with two methyl groups at the 2 position and a hydroxyl group at the 4 position. Vitamin E acetate is commonly added to moisturizers, sunscreens, and anti-aging products for its ability to nourish and protect the skin from UV damage and premature aging. In dietary supplements, it is used for its potential health benefits, including providing immune support and promoting overall well-being. However, there have been concerns about the safety of vitamin E acetate when used in vaping products, as it has been linked to severe lung injuries in some cases.

Upstream product

• 62113-84-2 7-methanesulfonyloxy-2,2-dimethyl-chroman-4-one 
• 3780-33-4 2,3-dihydro-2,2-dimethylbenzo[b]pyran-4-one 
• 118-93-4 o-hydroxyacetophenone 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 100942-29-8 2,2-dimethyl-4-keto-7-tosyloxy-benzopyran 

Downstream Products

• 1630952-60-1 8-(2,2-dimethylchroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 
• 58740-82-2 (3S,4S)-3,4-epoxy-2,2-dimethylchromane 
• 58740-82-2 (3R,4R)-3,4-epoxy-2,2-dimethylchromane 
• 264265-13-6 bis[4-(dimethylamino)phenyl](2,2-dimethyl-3-chromenyl)methanol 
• 264264-98-4 bis[4-(dimethylamino)phenyl](2,2-dimethyl-5-chromenyl)methanol 

Relevant articles and documents

Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst

A very simple and inexpensive catalytic system based on abundant manganese as transition metal and on an inexpensive phosphine-free bidendate ligand, 2-(aminomethyl)pyridine, has been developed for the reduction of a large variety of carbonyl derivatives with 2-propanol as hydrogen donor. Remarkably, the reaction proceeds at room temperature with low catalyst loading (down to 0.1 mol %) and exhibits a good tolerance toward functional groups. High TON (2000) and TOF (3600 h-1) were obtained.

Silylation-based kinetic resolution of monofunctional secondary alcohols

The nucleophilic small molecule catalyst (-)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective silylation. Optimization of this new methodology allows for selectivity factors up to 25 utilizing commercially available reagents and mild reaction conditions.

Synthesis and activity of novel and selective Iks-channel blockers

Since the discovery of the IKs-potassium channel as the slowly activating component of the delayed rectifier current (Ik) in cardiac tissue, the search for blockers of this current has been intense. During the screening of KATP