7165-07-3

Basic information

• Product Name: Methyl 4-isopropyl-pyrrole-2-carboxylate
• Synonyms: Methyl 4-isopropyl-pyrrole-2-carboxylate
• CAS NO: 7165-07-3
• Molecular Formula: C9H13NO2
• Molecular Weight: 0
• Mol File: 7165-07-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 272.7°C at 760 mmHg
• Flash Point: 118.7°C
• Appearance: /
• Density: 1.073g/cm³
• Vapor Pressure: 0.00599mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: Methyl 4-isopropyl-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-isopropyl-pyrrole-2-carboxylate(7165-07-3)
• EPA Substance Registry System: Methyl 4-isopropyl-pyrrole-2-carboxylate(7165-07-3)

Safety Data

• Hazardous Substances Data: 7165-07-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H13NO2/c1-6(2)7-4-8(10-5-7)9(11)12-3/h4-6,10H,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 90087-23-3 4-isopropyl-2-pyrrolecarboxylic acid 
• 73405-97-7 2-iso-Propyl-3-ethoxyacrolein 
• 915230-28-3 4-isopropyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester 
• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 75-29-6 isopropyl chloride 
• 156237-78-4 4-bromopyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 934-05-4 methyl 4-bromo-1H-pyrrole-2-carboxylate 
• 915230-27-2 3-hydroxy-4-isopropyl-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester 

Downstream Products

• 90087-23-3 4-isopropyl-2-pyrrolecarboxylic acid 
• 90483-41-3 4-isopropyl-proline 
• 101603-31-0 4-isopropyl-1-(4-nitro-benzoyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 99176-42-8 4-isopropyl-pyrrolidine-2-carboxylic acid ethyl ester 

Relevant articles and documents

PRC1 INHIBITORS AND METHODS OF TREATMENT THEREWITH

Provided herein are small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) activity, and methods of use thereof for the treatment of disease, including leukemia and other cancers, as well as other diseases dependent on the activity of PRC1.

PHENYL-3-{ (3- (1H- PYRROL- 2 -YL) - [1 , 2 , 4] 0XADIAZ0L-5-YL] PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I) as positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the treatment or prevention of central nervous system disorders such as for example, cognitive decline, both positive and negative symptoms in schizophrenia as well as other central or peripheral nervous system disorders in which the mGluR5 subtype of glutamate metabotropic receptor is involved. The invention is also directed to pharmaceutical compounds and compositions in the prevention or treatment of such diseases in which mGluKi is involved. W represents (C4-C7)cycloalkyl, (C3-C7)heterocycloalkyl , (C3-C7)heterocycloalkyl-(C1-C3)alkyl or (C3-C7)heterocycloalkenyl ring; represents a (C5-C7)heteroeycloalkyl, (C5-C7)heterocycloalkeiiyl ring or a heteroaryl group of formula (a), (b), (c), (d), (e), (f), (g), (i). Q denotes a cycloalkyl, an aryl or heteroaryl group of formula (j), (k), (l), (m), (n). A is azo -N=N-, ethyl, ethenyl, ethynyl, -NR8C(=O)-, -NR8C(=O)-O-, -NR8C(=O)-NR9, NR8S(=O)2-, -C(=O)NR8-, -O-C(=O)NR8-, -S-, -S(=O)-, -S(=O)2-, -S(C=O)2NR8-, -C(=0)-0-, -0-C(=0)-, -C(=NR8)NR9-, C(C=NOR8)NR9- , -NR8C(=NOR9)-, =N-0-, -0-N=CH- or a group aryl or heteroaryl of formula, (o), (p), (q), (r), (s), (t), (u), (v), (w), (x). The other substituents are defined in the claims.