7182-42-5

Basic information

• Product Name: 3-chloro-1-(4-hydroxy-3-methoxyphenyl)propan-1-one
• CAS NO: 7182-42-5
• Molecular Formula: C₁₀H₁₁ClO₃
• Molecular Weight: 214.6455
• Mol File: 7182-42-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 378.2°C at 760 mmHg
• Flash Point: 182.5°C
• Density: 1.253g/cm³
• Vapor Pressure: 2.95E-06mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 3-chloro-1-(4-hydroxy-3-methoxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-1-(4-hydroxy-3-methoxyphenyl)propan-1-one(7182-42-5)
• EPA Substance Registry System: 3-chloro-1-(4-hydroxy-3-methoxyphenyl)propan-1-one(7182-42-5)

Safety Data

• Hazardous Substances Data: 7182-42-5(Hazardous Substances Data)

Upstream product

• 2196-18-1 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 2983-65-5 1-(4-hydroxy-3-methoxyphenyl)-2-propene-1-one 
• 2196-18-1 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone 

Relevant articles and documents

Enzymatic Specific Production and Chemical Functionalization of Phenylpropanone Platform Monomers from Lignin

Enzymatic catalysis is an ecofriendly strategy for the production of high-value low-molecular-weight aromatic compounds from lignin. Although well-definable aromatic monomers have been obtained from synthetic lignin-model dimers, enzymatic-selective synthesis of platform monomers from natural lignin has not been accomplished. In this study, we successfully achieved highly specific synthesis of aromatic monomers with a phenylpropane structure directly from natural lignin using a cascade reaction of β-O-4-cleaving bacterial enzymes in one pot. Guaiacylhydroxylpropanone (GHP) and the GHP/syringylhydroxylpropanone (SHP) mixture are exclusive monomers from lignin isolated from softwood (Cryptomeria japonica) and hardwood (Eucalyptus globulus). The intermediate products in the enzymatic reactions show the capacity to accommodate highly heterologous substrates at the substrate-binding sites of the enzymes. To demonstrate the applicability of GHP as a platform chemical for bio-based industries, we chemically generate value-added GHP derivatives for bio-based polymers. Together with these chemical conversions for the valorization of lignin-derived phenylpropanone monomers, the specific and enzymatic production of the monomers directly from natural lignin is expected to provide a new stream in “white biotechnology” for sustainable biorefineries.