718611-17-7

Basic information

• Product Name: (S)-N-BOC-3-AMINO-3-PHENYL-PROPAN-1-OL
• Synonyms: Boc-(S)-3-amino-3-phenylpropan-1-ol;(S)-N-Boc-3-amino-3-phenylpropan-1-ol;(S)-Boc-3-AMino-3-phenylpropan-1-ol;Carbamic acid,N-[(1S)-3-hydroxy-1-phenylpropyl]-, 1,1-dimethylethyl ester;(S)-tert-butyl 3-hydroxy-1-phenylpropylcarbamate
• CAS NO: 718611-17-7
• Molecular Formula: C₁₄H₂₁NO₃
• Molecular Weight: 251.32
• Mol File: 718611-17-7.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 404.6 °C at 760 mmHg
• Flash Point: 198.5 °C
• Appearance: /
• Density: 1.083 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-N-BOC-3-AMINO-3-PHENYL-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-BOC-3-AMINO-3-PHENYL-PROPAN-1-OL(718611-17-7)
• EPA Substance Registry System: (S)-N-BOC-3-AMINO-3-PHENYL-PROPAN-1-OL(718611-17-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 718611-17-7(Hazardous Substances Data)

Usage

General Description

(S)-N-BOC-3-AMINO-3-PHENYL-PROPAN-1-OL is a chemical compound that belongs to the class of amino alcohols. It is a compound that contains a BOC-protected amine group, a phenyl group, and a propanol group. The BOC group, which stands for tert-butoxycarbonyl, is a protective group for amines, allowing for selective transformations of the amine functionality. (S)-N-BOC-3-AMINO-3-PHENYL-PROPAN-1-OL may be used in organic synthesis as a building block for the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, it may have applications in medicinal chemistry and drug discovery due to its potential biological activity.

Upstream product

• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 4248-19-5 tert-butyl carbazate 
• 135865-78-0 tert-butyl (1S)-3-oxo-1-phenylpropylcarbamate 
• 1624-53-9 2-(benzylideneamino)phenol 
• 100-52-7 benzaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 150884-50-7 benzaldehyde N-boc imine 
• 765922-42-7 (S)-propyl 3-amino-3-phenylpropanoate 
• 622830-41-5 (+/-)-β-phenylalanine propyl ester 
• 3646-50-2 3-Amino-3-phenylpropionic acid 
• 146924-91-6 (-)-cis-(3S,4R)-3-hydroxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone 
• 186613-02-5 cis-1-p-methoxyphenyl-3-acetoxy-4-phenylazetidin-2-one 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 37088-64-5 (S)-4-phenyl-2-azetidinone 

Downstream Products

• 1398626-52-2 (S)-4-amino-4-phenylbutyric acid sodium salt 
• 1398626-55-5 ((S)-3-cyano-1-phenylpropyl)carbamic acid tert-butyl ester 
• 949096-34-8 (S)-4-amino-4-phenylbutan-1-ol 
• 1150560-58-9 methanesulfonic acid (S)-3-tert-butoxycarbonylamino-3-phenylpropyl ester 
• 1630982-20-5 (S)-tert-butyl (3-amino-1-phenylpropyl)carbamate 
• 376348-70-8 tert-butyl (1S)-3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-exo-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylcarbamate 
• 376348-71-9 (S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropan-1-amine 
• 376348-65-1 maraviroc 
• 718611-16-6 C₂₈H₄₀N₂O₆S₂ 
• 674782-29-7 4,4-difluoro-N-[(1S)-3-[exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane-8-yl]-1-phenylpropyl]cyclohexane1-formamide 

Relevant articles and documents

Synthesis method of dapoxetine impurities

The invention provides a synthesis method of dapoxetine impurities, which comprises the following synthesis steps of: reacting (S)-3-amino-3-phenyl propanol with Boc anhydride to obtain a compound B; reducing the compound B under the action of a reducing agent to obtain a dapoxetine impurity 1; reacting the impurity 1 with 1-fluoronaphthalene under the action of alkali to obtain an impurity 2; and reacting the impurity 2 with chloroformate to obtain an impurity 3. According to the synthesis method of the dapoxetine impurities, the three dapoxetine impurities can be obtained in sequence, the starting raw materials are wide in source, the cost is low, the synthesis steps are short, all the steps are conventional experiment operation, special reagents or toxic reagents do not need to be used, and the prepared dapoxetine impurity products are high in purity and do not need tedious purification operation. The synthesized three impurities are applied to dapoxetine hydrochloride quality control, are helpful for perfecting the quality standard of dapoxetine hydrochloride, and have important meanings for improving the quality of dapoxetine hydrochloride raw material medicines and preparations thereof and the medication safety.

Chiral N,N′-Dioxide/Tm(OTf)3 Complex-Catalyzed Asymmetric Bisvinylogous Mannich Reaction of Silyl Ketene Acetal with Aldimines

An enantioselective bisvinylogous Mannich reaction of silyl ketene acetal with aldimines has been realized by using a chiral N,N′-dioxide/Tm(OTf)3 complex as catalyst, providing an effective method to synthesize chiral ζ-amino-α,β,γ,δ-unsaturated carbonyl compounds. (Figure presented.).

Synthetic method for novel chiral ligand, metal chelate, multiple unnatural amino acids, maraviroc and key intermediate thereof

The invention discloses a synthetic method for a novel chiral ligand, a metal chelate, multiple unnatural amino acids, maraviroc and a key intermediate thereof. According to the synthetic method, (R)-2-methylproline is selected as a starting material, and asymmetrical resolution is induced by utilizing a nickel chelate, so that (S)-beta3-amino acid is obtained, and (S)-3-amino-3-phenylpropionic acid is taken as the key intermediate for synthesizing maraviroc, so that yield is high, and ee value reaches more than or equal to 98.2%. The method disclosed by the invention has the advantages that source of raw materials is wide, conditions of a synthetic process are mild, control is easy, and optical purity of products is high.