71862-04-9

Basic information

• Product Name: N-(2-methoxy-4-nitrophenyl)formamide
• CAS NO: 71862-04-9
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.1601
• Mol File: 71862-04-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 446.4°C at 760 mmHg
• Flash Point: 223.8°C
• Density: 1.38g/cm³
• Vapor Pressure: 3.64E-08mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: N-(2-methoxy-4-nitrophenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methoxy-4-nitrophenyl)formamide(71862-04-9)
• EPA Substance Registry System: N-(2-methoxy-4-nitrophenyl)formamide(71862-04-9)

Safety Data

• Hazardous Substances Data: 71862-04-9(Hazardous Substances Data)

Upstream product

• 97-52-9 2-methoxy-4-nitrophenylamine 
• 109-94-4 formic acid ethyl ester 
• 23896-88-0 formic acid o-anisidide 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 97-52-9 2-methoxy-4-nitrophenylamine 
• 1235492-49-5 ethyl 1-(2-methoxy-4-nitrophenyl)-1H-imidazole-4-carboxylate 

Relevant articles and documents

Preparation method of 2-methoxy-4-nitroaniline

The invention discloses a preparation method of 2-methoxy-4-nitroaniline. The preparation method comprises the following steps of: carrying out acetylation reaction of o-methoxyaniline and acetic acid, discharging water generated in the acetylation reaction process from a reaction system, dropwisely adding fuming nitric acid into the prepared acetic acid solution of the o-methoxyacetanilide to carry out nitration reaction, adding deionized water after the nitration reaction is finished and then filtering, adding the prepared 2-methoxy-4-nitroaniline into an alkali solution to carry out hydrolysis reaction; after the hydrolysis reaction is finished, cooling the prepared reaction solution, and filtering to obtain 2-methoxy-4-nitroaniline. By adopting the method to synthesize 2-methoxy-4-nitroaniline, the acylation reaction cost is low, the nitration reaction selectivity is high, the discharge of three wastes is reduced, the production cost is reduced, the product purity is high, the yield is high, and the 2-methoxy-4-nitroaniline has a good industrial application value.

A novel method for preparing isocyanides from N-substituted formamides with chlorophosphate compounds

Treatment of N-substituted formamides with chlorophosphate compounds such as PhOPOCl2, EtOPOCl2, Me2NPOCl2, and (PhO)2POCl and tertiary amines such as triethylamine, pyridine, and N,N-diisopropylethylamine produced the corresponding isocyanides in high yields. This method can be used to prepare various alkyl and aryl isocyanides. Georg Thieme Verlag Stuttgart · New York.