7187-62-4 Usage
Description
Pyrvinium is a quinolinium ion derivative characterized by a 1-methylquinolinium structure with a dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is an anthelminthic drug primarily active against pinworms and has demonstrated potential as an anticancer agent.
Uses
Used in Pharmaceutical Industry:
Pyrvinium is used as an anthelminthic agent for the treatment of pinworm infections. Its mode of action involves disrupting the neuromuscular function of the parasites, leading to their paralysis and subsequent elimination from the host.
Used in Anticancer Applications:
Pyrvinium and its salts are employed as anticancer agents, particularly in the treatment of various types of cancer. The exact mechanisms of action are still under investigation, but they are believed to involve the disruption of cellular processes and signaling pathways that contribute to cancer cell survival and proliferation.
Used in Drug Delivery Systems:
Similar to gallotannin, pyrvinium may also benefit from novel drug delivery systems to enhance its applications and efficacy against cancer cells. These systems could potentially improve the delivery, bioavailability, and therapeutic outcomes of pyrvinium by employing various organic and metallic nanoparticles as carriers.
Check Digit Verification of cas no
The CAS Registry Mumber 7187-62-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,8 and 7 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7187-62:
(6*7)+(5*1)+(4*8)+(3*7)+(2*6)+(1*2)=114
114 % 10 = 4
So 7187-62-4 is a valid CAS Registry Number.
7187-62-4Relevant articles and documents
New synthesis of pyrvinium that inhibits the β-catenin/Tcf4 pathway
Mao, Yongjun,Lin, Nan,Tian, Wang,Huang, Ziwei,An, Jing
, p. 1179 - 1185 (2012/08/28)
A new and converged route is described for synthesis of pyrvinium, an anthelmintic and antitumor agent. This method uses easily obtained materials and simple and practical reactions, including the key Friedlaender condensation, to form the quinoline ring. The final product is generated through eight steps, with 23% yield and 96.6% purity (HPLC). This synthetic pyrvinium effectively inhibits β-catenin/Tcf4 driven TOP-luciferase activity, with an IC50 value 50 of 0.54 ± 0.06 μM.
