7188-22-9

Basic information

• Product Name: 1-Phenylphthalazine
• Synonyms: 1-Phenylphthalazine
• CAS NO: 7188-22-9
• Molecular Formula: C₁₄H₁₀N₂
• Molecular Weight: 206.24
• Mol File: 7188-22-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 174-175℃
• Appearance: /
• Density: 1.176
• CAS DataBase Reference: 1-Phenylphthalazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenylphthalazine(7188-22-9)
• EPA Substance Registry System: 1-Phenylphthalazine(7188-22-9)

Safety Data

• Hazardous Substances Data: 7188-22-9(Hazardous Substances Data)

Usage

Heterocyclic compound

Consisting of a phthalazine ring system 1-Phenylphthalazine contains a ring structure made up of carbon and nitrogen atoms, which is characteristic of heterocyclic compounds.

Phenyl group attachment

Attached to one of the nitrogen atoms A phenyl group, which is a benzene ring with a single carbon-carbon double bond, is connected to the phthalazine ring system via one of the nitrogen atoms.

Use in organic synthesis

Building block 1-Phenylphthalazine serves as a starting material or intermediate in the synthesis of more complex organic compounds.

Pharmaceutical research

Potential applications in drug discovery The compound may be used as a precursor or template for the development of new pharmaceuticals.

New materials development

Possible role in creating new materials 1-Phenylphthalazine may be utilized in the design and synthesis of novel materials with unique properties.

Biological activities

Being studied for potential effects Researchers are investigating the possible biological activities of 1-Phenylphthalazine, including its role as an antioxidant and enzyme inhibition capabilities.

Antioxidant properties

Potential role as an antioxidant 1-Phenylphthalazine may have the ability to neutralize harmful free radicals and protect cells from oxidative damage.

Enzyme inhibition

Ability to inhibit specific enzymes The compound may be able to interfere with the activity of certain enzymes, which could have therapeutic applications.

Further research needed

Limited understanding of properties and uses While 1-Phenylphthalazine has shown promise in various areas, more research is required to fully comprehend its properties and potential applications.

Upstream product

• 65997-87-7 (E,Z)-Benzaldehyde azine 
• 204520-35-4 (4-Methoxy-phenyl)-(4-phenyl-phthalazin-1-yl)-methanone 
• 24469-50-9 t-butyl 3-benzylidenecarbazate 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 100-52-7 benzaldehyde 
• 774506-23-9 1-phenyl-1,2,3,4-tetrahydro-phthalazine 
• 5784-45-2 1-chlorophthalazine 
• 98-80-6 phenylboronic acid 
• 253-52-1 PHTHALAZINE 
• 100-58-3 phenylmagnesium bromide 
• 119-61-9 benzophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 10132-01-1 1-chloro-4-phenyl-phthalazine 
• 10034-85-2 hydrogen iodide 

Downstream Products

• 13225-63-3 2,3-Dihydro-4-phenyl-1H-benzindene 
• 101277-90-1 1-(2′-hydroxyphenyl)naphthalene 
• 774506-23-9 1-phenyl-1,2,3,4-tetrahydro-phthalazine 
• 26641-30-5 4-isopropylidene-1,1-dimethyl-7-phenyl-1,11b-dihydro-[1,3]oxazino[4,3-a]phthalazin-2-one 

Relevant articles and documents

Regiocontrolled and Stereoselective Syntheses of Tetrahydrophthalazine Derivatives using Radical Cyclizations

Tetrahydrophthalazine derivatives have found important applications in pharmaceutical research, but existing synthetic methods are unable to access them regio- and stereoselectively. Here, a new approach is presented that addresses these challenges by utilizing a 6-endo-trig radical cyclization in the key step. The desired tetrahydrophthalazines can be accessed in high yields (55–98 %) and high diastereoselectivities for the trans-product (>95:5) starting either from readily accessible hydrazones, or from the corresponding aldehydes and substituted Boc-hydrazides in a one-pot process. The synthetic versatility of the tetrahydrophthalazine core was demonstrated by its straightforward conversion to dihydro-phthalazines, phthalazines, or pyrazolo dione derivatives. Furthermore, the N?N bond was reduced to afford a new route to 1,4-diamines.

Cycloadditions of siloxy alkynes with 1,2-diazines: From reaction discovery to identification of an antiglycolytic chemotype

Cycloaddition uncovered: The title reaction produces novel polycyclic compounds with high efficiency and excellent diastereoselectivity under mild reaction conditions. A small-molecule library, synthesized using this reaction, yielded a novel chemotype which inhibited glycolytic ATP production by blocking glucose uptake in CHO-K1 cells. DMF=N,N-dimethylformamide, Tf= trifluoromethanesulfonyl, TIPS=triisopropylsilyl. Copyright

Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase

This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferation comprising the administration thereto of an EGF and/or PDGF receptor inhibiting effective amount of said bis mono- and/or bicyclic aryl and/or heteroaryl compound and to the preparation of said compounds and their use in pharmaceutical compositions used in this method.