719282-77-6Relevant articles and documents
Enantioselectivity of α-Benzyl-α-methyl-γ -butyrolactone-Mediated Modulation of Anticonvulsant Activity and GABA A Receptor Function
Gonzales, Eric B.,Bell-Horner, Cathy L.,De La Cruz, Maria Antonette M.,Ferrendelli, James A.,Covey, Douglas F.,Dillon, Glenn H.
, p. 677 - 683 (2004)
Alkyl-substituted butyrolactones have both inhibitory and stimulatory effects on GABAA receptors. Lactones with small alkyl substitutions at the α-position positively modulate the channel, whereas β-substituted lactones tend to inhibit the GABA