719288-75-2

Basic information

• Product Name: 5'-dimethoxytrityl-2'-tosyl-N₂-isobutyrylguanosine
• Synonyms: 5'-dimethoxytrityl-2'-tosyl-N₂-isobutyrylguanosine
• CAS NO: 719288-75-2
• Molecular Weight: 809.897
• Mol File: 719288-75-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-dimethoxytrityl-2'-tosyl-N₂-isobutyrylguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-dimethoxytrityl-2'-tosyl-N₂-isobutyrylguanosine(719288-75-2)
• EPA Substance Registry System: 5'-dimethoxytrityl-2'-tosyl-N₂-isobutyrylguanosine(719288-75-2)

Safety Data

• Hazardous Substances Data: 719288-75-2(Hazardous Substances Data)

Upstream product

• 118-00-3 G 
• 87865-78-9 3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-N₂-isobutyrylguanosine 
• 64350-24-9 N²-isobutyryl-2'-deoxyguanosine 
• 132471-94-4 N²-isobutyryl-2'-O-p-toluenesulfonyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanyl)guanosine 
• 132471-95-5 N²-isobutyryl-2'-O-p-toluenesulfonylguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 170236-41-6 3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine 
• 719288-80-9 N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine 
• 170236-39-2 N-[9-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxytetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide 
• 68892-41-1 5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine 

Relevant articles and documents

Improved and Reliable Synthesis of 3′-Azido-2′,3′ -dideoxyguanosine Derivatives

An improved synthesis of N2-protected-3′-azido-2′ ,3′-dideoxyguinosine 20 and 23 is described. Deoxygenation of 2′-O-alkyl (and/or aryl) sulfonyl-5′-dimethoxytritylguanosine coupled with [1,2]-hydride shift rearrangement gave protected 9-(2-deoxythreo-pentofuranosyl)guanines (10, 12 and 16). This rearrangement was accomplished in high yield with a high degree of stereoselectivity using lithium triisobutylborohydride (L-Selectride R). Compounds 10, 12 and 16 were transformed into 3′-O-mesylates (18 and 21), which can be used for 3′-substitution. The 3′-azido nucleosides were obtained by treatment of 18 and 21 with lithium azide. This procedure is reproducible with a good overall yield.