720-43-4

Basic information

• Product Name: Ethanone, 2-fluoro-1,2-diphenyl-
• CAS NO: 720-43-4
• Molecular Formula: C14H11FO
• Molecular Weight: 214.239
• Mol File: 720-43-4.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-fluoro-1,2-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-fluoro-1,2-diphenyl-(720-43-4)
• EPA Substance Registry System: Ethanone, 2-fluoro-1,2-diphenyl-(720-43-4)

Safety Data

• Hazardous Substances Data: 720-43-4(Hazardous Substances Data)

Upstream product

• 72223-17-7 1-trimethylsilyloxy-1,2-diphenylethylene 
• 1589-82-8 phenylmagnesium bromide 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 321-75-5 α-bromo-α-fluorophenylethanone 
• 98-80-6 phenylboronic acid 
• 365-01-5 2,2-difluoro-2-phenylacetophenone 
• 591-50-4 iodobenzene 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 1494-20-8 2,2-difluoro-1,2-diphenylethan-1-ol 
• 75-05-8 acetonitrile 
• 780-69-8 triethoxyphenylsilane 
• 41463-86-9 4,4,4-trifluoro-3-hydroxy-1-phenylbut-2-en-1-one 
• 98-86-2 acetophenone 
• 450-95-3 2-fluoroacetophenone 

Downstream Products

• 14224-99-8 2-methyl-4,5-diphenyloxazole 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 6963-24-2 2,3,5,6-tetraphenyl-1,4-dioxine 
• 365-01-5 2,2-difluoro-2-phenylacetophenone 
• 1341230-63-4 2-fluoro-1,2,2-triphenylethan-1-one 
• 14090-31-4 meso-1,2-Difluoro-1,2-diphenylethane 

Relevant articles and documents

FLUORINATING AGENT AND METHOD FOR PRODUCING FLUORINE-CONTAINING COMPOUNDS

The present invention provides the compound represented in general formula (A1) [Ar1 is a C6-14 aryl group or a C5-14 nitrogen-containing heteroaryl group, substituted with at least two electron-attracting groups; R1 is a C1-30 alkyl group, a C6-14 aryl group, or a C5-14 nitrogen-containing heteroaryl group; the electron-attracting group is a halogen atom, a trihalomethyl group, a cyano group, a nitro group, -CO2R or -CO2N(R)2 (the Rs independently represent C1-30 alkyl groups)].

Bench-Stable Electrophilic Fluorinating Reagents for Highly Selective Mono- and Difluorination of Silyl Enol Ethers

Efficient methods for the synthesis of fluorinated compounds have been intensively studied, recently. Development of practical fluorinating reagents is indispensable for this purpose. Herein, bench-stable electrophilic fluorinating reagents were synthesized as N-fluorobenzenesulfonimide (NFSI) substitutes. Reagents obtained by replacing one of the NFSI sulfonyl groups with an acyl group led to the highly selective monofluorination of silyl enol ethers with suppression of undesired overreaction, that is, difluorination. On the other hand, reagents bearing electron-withdrawing substituents at NFSI benzenesulfonyl groups efficiently facilitated the difluorination of silyl enol ethers under base-free conditions. Thus, both mono- and difluorinated target materials were prepared from the same substrate.

Preparation method of monofluorobromoacetone derivative

The invention relates to a preparation method of a monofluorobromoacetone derivative. The method comprises the following steps: mixing a compound as shown in a formula (1) with a catalyst, a ligand, alkali and a solvent, performing reacting with a compound as shown in a formula (2) under the protection of N2 until the reaction is complete, extracting and separating the obtained reaction solution to obtain the monofluorobromoacetone derivative as shown in a formula (3), wherein R1 is phenyl, substituted phenyl or heterocyclic ring; R2 is phenyl or substituted phenyl. Compared with the prior art, the method has the advantages of high reaction selectivity, milder conditions and shorter reaction time.