7205-63-2Relevant articles and documents
Production of alkyl sulfide nitriphenyl
-
Paragraph 0051; 0052, (2016/12/16)
PROBLEM TO BE SOLVED: To provide a production method of nitrophenyl alkyl sulfide capable of efficiently obtaining the nitrophenyl alkyl sulfide of a high purity in good yield. SOLUTION: The production method of the nitrophenyl alkyl sulfide includes a process for mixing a rough product that contains specific nitrophenyl alkyl sulfide with an aliphatic hydrocarbon to extract the nitrophenyl alkyl sulfide to the aliphatic hydrocarbon. COPYRIGHT: (C)2013,JPO&INPIT
A kinetic investigation, supported by theoretical calculations, of steric and ring strain effects on the oxidation of sulfides and sulfoxides by dimethyldioxirane in acetone
Hanson, Peter,Hendrickx, Ramon A. A. J.,Lindsay Smith, John R.
supporting information; experimental part, p. 65 - 84 (2011/01/07)
The oxidations of alkyl 4-nitrophenyl, and dialkyl, sulfides and sulfoxides by dimethyldioxirane in acetone occur by concerted mechanisms but the sulfides respond differently from the sulfoxides to variation in the alkyl group. The reactions of the sulfides are inhibited by the steric effects of alkyl groups and these predominate over their inductive effects. By contrast, the reactions of these limited sets of sulfoxides are insensitive to alkyl steric effects but there is an indication of steric acceleration when a broader set of sulfoxides is considered. This behaviour is rationalised in terms of the differences in dipolar charge and its solvation between the ground state and transition state for the two types of substrate. The oxidations of cyclic sulfides and sulfoxides also exhibit contrasting behaviour. The reactivity of the sulfides is insensitive to ring strain but is explicable in frontier orbital terms whereas that of the sulfoxides is partly dependent upon the change in ring strain between reactant and product on oxidation, a difference rationalised in terms of the relative positions of the transition states in the reaction coordinates of the two oxidations. The reactivity of 4-, 5- and 6-membered cyclic sulfoxides is also dependent on a ring-size related property of the transition state. Calculations at the B3-LYP/6-31G* level of density functional theory on both ground states and transition states, including simulation of solvation by acetone, strongly support the mechanistic conclusions reached in this and earlier work.
Thiazolopyrimidine modulators of TRPV1
-
Page/Page column 14-15, (2008/06/13)
Certain TRPV1-modulating thiazolopyrimidine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
