7205-91-6Relevant articles and documents
Novel process for synthesizing 2 -fluorocyclopropylamine with high selectivity and asymmetric synthesis
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Paragraph 0041-0044, (2021/10/13)
A novel highly selective asymmetric synthesis process of 2 -fluorocyclopropylamine (Structural I). The method provided by the invention uses 1 - fluorine -1 - benzene (propylene) sulfonyl methane and chiral epichlorohydrin to construct chiral cyclopropane under basic conditions, and a new synthetic route not only achieves a special cis-trans selectivity, but also has a highly specific stereoselectivity. The synthesis route is efficient, the reaction condition is mild, the method is suitable for large industrial production in a green environment, 2 -fluorocyclopropylamine production cost is greatly reduced.
A Manganese N-Heterocyclic Carbene Catalyst for Reduction of Sulfoxides with Silanes
Sousa, Sara C. A.,Carrasco, Carlos J.,Pinto, Mara F.,Royo, Beatriz
, p. 3839 - 3843 (2019/06/24)
The first reduction of sulfoxides catalysed by a well-defined manganese complex is described. A variety of sulfoxides are reduced to the corresponding sulfides in high yields using phenylsilane, diphenylsilane, and the economically feasible 1,1,3,3-tetramethyldisiloxane (TMDS) as reducing agents in the presence of a Mn-NHC complex. The reaction is performed under air and without the need of any additive. The involvement of radicals in the catalytic reaction is probed by spin-trap experiments.
An electrophilic reagent for the synthesis of OCHFMe-containing molecules
Carbonnel, Elodie,Pannecoucke, Xavier,Besset, Tatiana,Jubault, Philippe,Poisson, Thomas
supporting information, p. 2491 - 2493 (2018/03/21)
Herein the synthesis of a novel and bench stable electrophilic reagent to construct the OCFHMe motif from O-nucleophiles has been described. This sulfonium salt, readily obtained in 5 steps, reacted with various phenols and alcohols. The resulting products, including complex molecules, were obtained in good yields. This reagent was also used for the functionalization of thiol derivatives.