72083-72-8

Basic information

• Product Name: 1,2-dimethyl-3-nitro-1H-pyrrole
• CAS NO: 72083-72-8
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.1399
• Mol File: 72083-72-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 233.9°C at 760 mmHg
• Flash Point: 95.2°C
• Density: 1.22g/cm³
• Vapor Pressure: 0.0832mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 1,2-dimethyl-3-nitro-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dimethyl-3-nitro-1H-pyrrole(72083-72-8)
• EPA Substance Registry System: 1,2-dimethyl-3-nitro-1H-pyrrole(72083-72-8)

Safety Data

• Hazardous Substances Data: 72083-72-8(Hazardous Substances Data)

Usage

Chemical structure

Nitroaromatic compound with a pyrrole ring and two methyl groups attached to the 1 and 2 positions

Functional groups

Nitro group (-NO2), pyrrole ring, and two methyl groups (-CH3)

Applications

Building block in the synthesis of pharmaceuticals and agrochemicals

Chemical reactivity

Versatile intermediate for various organic reactions such as reduction, alkylation, and dehalogenation

Physical property

Characteristic red color

Additional uses

Dye or pigment in the production of various materials

Biological activities

Potential anti-inflammatory and anti-cancer properties

Upstream product

• 600-29-3 1,2-dimethylpyrrole 
• 72795-81-4 4-nitro-5-methyl-1-methylpyrrole-2-carboxylic acid 
• 72083-70-6 ethyl 4-nitro-5-methyl-1-methylpyrrole-2-carboxylate 
• 26477-34-9 2-Methyl-3-nitropyrrole 
• 74-88-4 methyl iodide 
• 183268-72-6 2,2,2-trichloro-1-(5-methyl-1H-pyrrol-2-yl)ethan-1-one 
• 25907-27-1 Ethyl 5-methyl-4-nitropyrrole-2-carboxylate 
• 37670-50-1 ethyl 5-methyl-1-methylpyrrole-2-carboxylate 
• 26477-37-2 5-Methyl-4-nitropyrrole-2-carboxylic acid 
• 3284-51-3 ethyl 5-methyl-1H-pyrrole-2-carboxylate 
• 636-41-9 2-methyl-1H-pyrrole 

Relevant articles and documents

Synthesis and nucleophilic properties of 1,2 -dialkyl-3-nitropyrroles and 1,5-dialkyl-4-nitropyrrole-2-carboxylic acid derivatives

1,2-Dialkyl-3-nitropyrroles 1 are versatile synthetic tools for obtaining substituted pyrrolidines or fused ring heterocycles such as pyrrolopyridines, pyrrolopyrimidines or pyrroloazepines. We have established a method for obtaining compounds related to structure 1 and studied the reactivity as a nucleophile of the benzylic type moiety in the alkyl residue bound to position 2.

PREPARATIVE ASPECTS OF THE NITRATION OF 1-METHYLPYRROLE DERIVATIVES. 13C NMR OF SOME NITROPYRROLES.

The nitration of 1-methylpyrrole and 1,2-dimethylpyrrole was studied and the products were characterized. It was found that the nitration of ethyl 1-methylpyrrole-2-carboxylate depends on the reaction conditions. **1**3C parameters have been determined for several 1-methyl substituted pyrrole- and nitropyrrole derivatives and the relationship between the observed and predicted **1**3C shifts for aromatic carbons is briefly discussed. It has been found that the determination of the direct **1**3C-**1H coupling constants in the pyrrole ring constitutes a useful tool for distinguishing alpha - and beta -positions.