72084-00-5Relevant articles and documents
Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors
éliás, Olivér,ágai-Csongor, éva,Domány, Gy?rgy,Keseru, Gy?rgy Miklós,Gere, Anikó,Kiss, Béla,Hellinger, éva,Vastag, Mónika,Gyertyán, István
, p. 2118 - 2122 (2014/05/06)
This Letter describes our attempts to elaborate dually acting compounds possessing serotonin re-uptake transporter inhibitor and serotonin 5-HT 2C receptor antagonist properties. A novel series of 1,3-diphenylureas and N-phenylbenzamides have thus been prepared and evaluated. Based on its in vitro and in vivo activities, as well as pharmacokinetic profile, compound 16a was identified as a lead compound. The synthesis and structure-activity relationship of this series of compounds is presented herein.
3-PHENYLOXY-3-PHENYL PROPANAMINES
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, (2008/06/13)
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