721-36-8

Basic information

• Product Name: 2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanol
• CAS NO: 721-36-8
• Molecular Formula: C₉H₆F₆O
• Molecular Weight: 244.1338
• Mol File: 721-36-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 204.3°C at 760 mmHg
• Flash Point: 77.4°C
• Density: 1.432g/cm³
• Vapor Pressure: 0.161mmHg at 25°C
• Refractive Index: 1.416
• CAS DataBase Reference: 2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanol(721-36-8)
• EPA Substance Registry System: 2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanol(721-36-8)

Safety Data

• Hazardous Substances Data: 721-36-8(Hazardous Substances Data)

Usage

Type of compound

Fluoro-derivative of ethanol

Constituents

Three fluorine atoms, a phenyl group

Usage

Solvent in chemical processes, reagent in organic synthesis

Known for

Strong solvent properties

Industries

Pharmaceutical industry, production of specialty chemicals

Applications

Manufacturing of polymers, synthesis of other fluorinated compounds

Potential applications

Medicine, antimicrobial and antifungal properties

Upstream product

• 721-37-9 2,2,2-trifluoro-3'-(trifluoromethyl)acetophenone 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 

Downstream Products

• 2925-57-7 1-chloro-1-(3-trifluoromethylphenyl)-2,2,2-trifluoroethane 
• 125888-96-2 Phosphorochloridic acid 2,2,2-trifluoro-ethyl ester 2,2,2-trifluoro-1-(3-trifluoromethyl-phenyl)-ethyl ester 
• 84877-49-6 Trifluoro-methanesulfonic acid 2,2,2-trifluoro-1-(3-trifluoromethyl-phenyl)-ethyl ester 
• 125888-92-8 Phosphorochloridic acid 2,2,3,3,4,4,5,5,5-nonafluoro-pentyl ester 2,2,2-trifluoro-1-(3-trifluoromethyl-phenyl)-ethyl ester 
• 60988-80-9 α-trifluoromethyl-m-trifluoromethylbenzyl dichlorophosphate 
• 921624-75-1 3-methyl-2-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethoxy}-2,3-dihydro-1,3,2-benzoxazaphosphole 
• 862731-94-0 2-[2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethoxy]-1,3,2-benzodioxaphospholene 
• 50562-21-5 Toluene-4-sulfonic acid 2,2,2-trifluoro-1-(3-trifluoromethyl-phenyl)-ethyl ester 
• 100664-07-1 Phosphoric acid bis-(2,2,2-trifluoro-ethyl) ester 2,2,2-trifluoro-1-(3-trifluoromethyl-phenyl)-ethyl ester 
• 50562-22-6 1,1,1-Trifluor-2-(m-trifluormethylphenyl)ethan 

Relevant articles and documents

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.

A robust and recyclable palladium catalyst [Pd0EnCat] has been prepared by ligand exchange of polyurea-encapsulated palladium(II) acetate with formic acid, resulting in deposition of Pd(0) in the support material; Pd0EnCat is shown to be a highly efficient transfer hydrogenation catalyst for chemoselective reduction of a wide range of aryl ketones to benzyl alcohols.

Reduction by a Model of NAD(P)H. 29. Kinetics and Isotope Effects for the Reduction of Substituted Trifluoroacetophenone

Kinetics for the reduction of substituted and unsubstituted α,α,α-trifluoroacetophenone by a model of NAD(P)H in acetonitrile in the presence and absence of a magenesium ion, a catalyst, has been studied.The catalyzed and uncatalyzed reactions show linear free-energy relationships.It is found that the magnesium ion retards the reaction of ceratain substituted trifluoroacetophenones.The kinetic isotope effect and the isotopic ratio in the product are also studied.These values vary depending on the substituent and on the presence or absence of the magnesium ion.The result indicates that there is at least one intermediate in the reaction and is discussed in relation to the stability of the intermediate as well as that of the transition states.