7210-81-3

Basic information

• Product Name: Neopentylphenylamine
• Synonyms: N-(2,2-Dimethylpropyl)aniline;Neopentylphenylamine;N-Neopentylbenzenamine
• CAS NO: 7210-81-3
• Molecular Formula: C₁₁H₁₇N
• Molecular Weight: 163.26
• Mol File: 7210-81-3.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Neopentylphenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: Neopentylphenylamine(7210-81-3)
• EPA Substance Registry System: Neopentylphenylamine(7210-81-3)

Safety Data

• Hazardous Substances Data: 7210-81-3(Hazardous Substances Data)

Upstream product

• 26029-60-7 N-(neopentylidene)aniline 
• 6625-74-7 N-pivaloylaniline 
• 51643-83-5 N-(phenylsulfanyl-methyl)-aniline 
• 594-19-4 tert.-butyl lithium 
• 89379-02-2 tert-butylmercury iodide 
• 15501-33-4 neopentyl iodide 
• 20732-26-7 lithium anilide 
• 630-18-2 tert-butyl isocyanide 
• 62-53-3 aniline 
• 630-19-3 pivalaldehyde 
• 75-84-3 2,2-dimethyl-propanol-1 
• 93-98-1 N-phenyl benzoyl amide 
• 75-98-9 Trimethylacetic acid 
• 98-95-3 nitrobenzene 

Downstream Products

• 20972-43-4 trans-azoxybenzene 
• 1536470-56-0 C₃₀H₄₈Li₂N₂O₂ 
• 635708-37-1 [AlMe₃(N-neopentylaniline)] 
• 26029-60-7 N-(neopentylidene)aniline 
• 75-98-9 Trimethylacetic acid 

Relevant articles and documents

BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant

A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3·Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3and hydride transfer from formic acid.

Simple reversible fixation of a magnetic catalyst in a continuous flow system: Ultrafast reduction of nitroarenes and subsequent reductive amination using ammonia borane

Continuous reductive amination of aldehydes with nitroarenes over a Pd-Pt-Fe3O4 catalyst was performed. We used NH3BH3 as not only a hydrogen source for nitro reduction, but also a reductant for imine reduction. Secondary aromatic amines were obtained in the continuous flow reaction in good to excellent yields.

Borrowing Hydrogen-Mediated N-Alkylation Reactions by a Well-Defined Homogeneous Nickel Catalyst

We report herein a well-defined and bench-stable azo-phenolate ligand-coordinated nickel catalyst which can efficiently execute N-alkylation of a variety of anilines by alcohol. We demonstrate that the redox-active azo ligand can store hydrogen generated during alcohol oxidation and redelivers the same to an in-situ-generated imine bond to result in N-alkylation of amines. The reaction has wide scope, and a large array of alcohols can directly couple to a variety of anilines. Mechanistic studies including deuterium labeling to the substrate establishes the borrowing hydrogen method from alcohols and pinpoints the crucial role of the redox-active azo moiety present on the ligand backbone. Isolation of the ketyl intermediate in its trapped form with a radical quencher and higher kH/kD for the alcohol oxidation step suggest altogether a hydrogen-atom transfer (HAT) to the reduced azo backbone to pave alcohol oxidation as opposed to the conventional metal-ligand bifunctional mechanism. This example clearly demonstrates that an inexpensive base metal catalyst can accomplish an important coupling reaction with the help of a redox-active ligand backbone.