72114-82-0Relevant articles and documents
The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor
Ducharme, Yves,Blouin, Marc,Brideau, Christine,Chateauneuf, Anne,Gareau, Yves,Grimm, Erich L.,Juteau, Helene,Laliberte, Sebastien,MacKay, Bruce,Masse, Frederic,Ouellet, Marc,Salem, Myriam,Styhler, Angela,Friesen, Richard W.
scheme or table, p. 170 - 174 (2010/10/21)
The discovery of novel and selective inhibitors of human 5-lipoxygenase (5-LO) is described. These compounds are potent, orally bioavailable, and active at inhibiting leukotriene biosynthesis in vivo in a dog PK/PD model. A major focus of the optimization
Amide derivatives
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, (2008/06/13)
The disclosure relates to novel 3,4-disubstituted-branched-chain-fluorinated-acylanilides, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess antiandrogenic activity. Representative of the compounds disclosed is 4-nitro-3-trifluoromethyl-(2-hydroxy-2-trifluoromethylpropionyl)anilide.
