7212-28-4

Basic information

• Product Name: Acetamide, 2-iodo-N-phenyl-
• CAS NO: 7212-28-4
• Molecular Formula: C8H8INO
• Molecular Weight: 261.062
• Mol File: 7212-28-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-iodo-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-iodo-N-phenyl-(7212-28-4)
• EPA Substance Registry System: Acetamide, 2-iodo-N-phenyl-(7212-28-4)

Safety Data

• Hazardous Substances Data: 7212-28-4(Hazardous Substances Data)

Usage

General Description

2-Iodo-N-phenylacetamide is a chemical compound that is also known as phenylacetamide, 2-iodo-. It is a derivative of acetamide and is commonly used in organic synthesis and pharmaceutical research. Acetamide, 2-iodo-N-phenyl- is identified by its molecular structure, which consists of a phenyl group attached to the nitrogen atom of the acetamide molecule, with an iodine atom attached to the phenyl ring. 2-Iodo-N-phenylacetamide is utilized as a building block in the production of various pharmaceutical agents and chemical intermediates. Its unique properties and reactivity make it a valuable tool in the development of new drugs and other organic compounds.

Upstream product

• 38020-81-4 2-iodoacetyl chloride 
• 62-53-3 aniline 
• 60-29-7 diethyl ether 
• 623-48-3 ethyl iodoacetae 
• 105-39-5 chloroacetic acid ethyl ester 
• 64-69-7 Iodoacetic acid 
• 75-11-6 diiodomethane 
• 103-71-9 phenyl isocyanate 
• 587-65-5 N-chloroacetyl-aniline 
• 615-43-0 2-iodophenylamine 
• 75-36-5 acetyl chloride 

Downstream Products

• 1106762-06-4 [2-{[(4-methylphenyl)sulfonyl]imino}pyrimidin-1(2H)-yl]-N-phenylacetamide 
• 1106762-10-0 N₂-[(4-methylphenyl)sulfonyl]-N₁-phenyl-N₂-pyrimidin-2-ylglycinamide 
• 1385049-62-6 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-phenylacetamide 
• 1387000-03-4 2-(6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-phenylacetamide 
• 103-70-8 Formanilid 
• 1458554-46-5 N-(phenyl)-2-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)acetamide 
• 1157933-49-7 N-(phenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetamide 
• 1157937-47-7 N-(phenyl)-2-(1H-pyrazol-1-yl)acetamide 

Relevant articles and documents

Synthesis and evaluation of moxifloxacin derivatives for effects on proliferation and apoptosis of NCI-H1299 cells

Eight novel moxifloxacin (MXF) derivatives 4a-h were synthesized by functional modification of the N-5-Aza ring. Their growth inhibitory activities on human non-small lung cancer cell NCI-H1299 and A549 were evaluated by the MTT colorimetric assay. Based on the half inhibitory concentration (IC50) values, we determined that compounds 4b was the most efficacious derivative (IC50 = 2.56 ± 0.07 μM for NCI-H1299 and IC50 = 13.69 ± 0.70 μM for A549, respectively) that inhibited the proliferation of NCI-H1299 cells. Of these, Compound 4b (1 – cyclopropyl – 6 – fluoro – 8 – methoxy – 4 – oxo – 7 – ((4aS,7aS) – 1 – (2 – oxo – 2 – (p – tolylamino) ethyl) hexahydro – 1H – pyrrolo [3,4-b] pyridine – 6(2H)-yl) – 1,4 – dihydroquinoline – 3-carboxylic acid) showed good potency against the growth of NCI-H1299 cells and also selectivity on HUVEC cells (IC50 > 500 μM). The dose-response relationship of the characteristic morphological changes of NCI-H1299 cells induced by Compound 4b was confirmed by AO/EB fluorescent staining. Furthermore, Compound 4b triggered apoptosis of NCI-H1299 in a concentration-dependent manner and arrested cells in the G0/G1 phase. These data indicate that the N-(p-tolyl)propanamide functionalized N-5-Aza ring of moxifloxacin may be a promising lead compound and candidate for the development of new agents against non-small-cell lung cancer.

With anti-prostate cancer activity of 2 - oxo - 2 - (aryl aniline) ethyl substituted star seriation of the medicinal composition (by machine translation)

The invention discloses a with anti-prostate cancer activity of 2 - oxo - 2 - (aryl aniline) ethyl substituted star seriation of the medicinal composition, its structure is of formula I, R1 Represents hydrogen or halogen or nitro or methyl or m

Design and synthesis of novel 4'-demethyl-4-deoxypodophyllotoxin derivatives as potential anticancer agents

A group of podophyllotoxin (PPT) derivatives (7a-j) were synthesized by conjugating aryloxyacetanilide moieties to the 4'-hydroxyl of 4'-demethyl-4-deoxypodophyllotoxin (DDPT), and their anticancer activity was evaluated. It was found that the most potent compound 7d inhibited the proliferation of three cancer cell lines with sub to low micromolar IC50 values. Furthermore, it was demonstrated that 7d induced cell cycle arrest in G2/M phase in MGC-803 cells, and regulated the expression of cell cycle check point proteins, such as cyclin A, cyclin B, CDK1, cdc25c, and p21. Finally, 4 mg/kg of 7d reduced the weights and volumes of HepG2 xenografts in mice. Our findings suggest that 7d might be a potential anticancer agent.