72131-33-0

Basic information

• Product Name: Sulotroban
• Synonyms: Sulotroban;4-[2-[(Phenylsulfonyl)amino]ethyl]phenoxyacetic acid;BM-13177;SKF-95587;Sulotraban;Acetic acid, 2-[4-[2-[(phenylsulfonyl)aMino]ethyl]phenoxy]-
• CAS NO: 72131-33-0
• Molecular Formula: C₁₆H₁₇NO₅S
• Molecular Weight: 335.37
• Mol File: 72131-33-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 551.7°C at 760 mmHg
• Flash Point: 287.5°C
• Appearance: /
• Density: 1.328g/cm³
• Vapor Pressure: 5.25E-13mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: Sulotroban(CAS DataBase Reference)
• NIST Chemistry Reference: Sulotroban(72131-33-0)
• EPA Substance Registry System: Sulotroban(72131-33-0)

Safety Data

• Hazardous Substances Data: 72131-33-0(Hazardous Substances Data)

Usage

Uses

Glomerulonephritis treatment.

InChI:InChI=1/C16H17NO5S/c18-16(19)12-22-14-8-6-13(7-9-14)10-11-17-23(20,21)15-4-2-1-3-5-15/h1-9,17H,10-12H2,(H,18,19)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 55458-77-0 4-(2-aminoethyl)-phenoxyacetic acid 
• 51-67-2 tyrosamine 
• 72131-29-4 ethyl 4-[2-(benzenesulphonylamino)-ethyl]-phenoxyacetate 
• 72131-28-3 N-(4-hydroxyphenethyl)benzenesulfonamide 

Downstream Products

• 72131-61-4 4-[2-(benzenesulphonylamino)-ethyl]-phenoxyacetamide 
• 72131-62-5 4-[2-(benzenesulphonylamino)-ethyl]-phenoxyacetanilide 
• 72131-64-7 4-[2-(benzenesulphonylamino)-ethyl]-phenoxyacetic acid 2-carboxyethylamide 
• 72131-63-6 4-[2-(Benzenesulphonylamino)-ethyl]-phenoxyacetic acid 2-ethoxycarbonylethylamide 
• 72131-66-9 4-{2-[4-(2-Benzenesulfonylamino-ethyl)-phenoxy]-acetylamino}-benzoic acid 
• 72131-65-8 4-{2-[4-(2-Benzenesulfonylamino-ethyl)-phenoxy]-acetylamino}-benzoic acid ethyl ester 
• 72131-68-1 [4-(2-{2-[4-(2-Benzenesulfonylamino-ethyl)-phenoxy]-acetylamino}-ethyl)-phenoxy]-acetic acid 
• 72131-67-0 [4-(2-{2-[4-(2-Benzenesulfonylamino-ethyl)-phenoxy]-acetylamino}-ethyl)-phenoxy]-acetic acid ethyl ester 
• 1202-66-0 N-acetyltyramine 
• 72131-32-9 4-[2-(benzenesulphonylamino)-ethyl]-phenoxyacetyl chloride 

Relevant articles and documents

Thromboxane A2 receptor antagonists. Synthesis and activities of phenylsulfonamido derivatives

A number of phenylsulfonamido derivatives have been synthesized and tested for their ability to inhibit: a) thromboxane A2/prostaglandin H2 (TXA2/PGH2) mimetic (U46619)-induced guinea pig platelet aggregation; b) aortic ring contraction; and c) binding of a radioiodinated TXA2/PGH2 mimetic (I-BOP) to platelets.In platelets, Kd values ranged from 9 nM to > 50 μM. pKb values in aortic rings ranged from 7.63 to 3.66 and in platelets from 7.7 to A high degree of correlation was observed between the Kd and pKb values found in the 3 sytems.Antagonist activity at the TXA2/PGH2 receptor was sensitive to both the substitution pattern of the 2 aromatic rings and the presence of heteroatoms.For 2 of the derivatives (4 and 11) molecular mechanics calculations were performed which indicated subtle structural differences that may account for the > 300-fold difference in potency observed for these analogs at the platelet TXA2/PGH2 receptor. thromboxane A2 / antagonist / platelet / artery / receptor / phenylsulfonamido derivative