72133-72-3

Basic information

• Product Name: Thiophene, 2-(4-iodophenyl)-
• CAS NO: 72133-72-3
• Molecular Formula: C10H7IS
• Molecular Weight: 286.136
• Mol File: 72133-72-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Thiophene, 2-(4-iodophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene, 2-(4-iodophenyl)-(72133-72-3)
• EPA Substance Registry System: Thiophene, 2-(4-iodophenyl)-(72133-72-3)

Safety Data

• Hazardous Substances Data: 72133-72-3(Hazardous Substances Data)

Upstream product

• 88016-29-9 μ-oxobis[(trifluoromethanesulfonato)(phenyl)iodine] 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 70010-48-9 1-(2-thienyl)-4-aminobenzene 
• 17763-80-3 para-nitrophenyl triflate 

Downstream Products

• 1056474-34-0 4,4,5,5-tetramethyl-2-(4-(thiophen-2-yl)phenyl)-1,3,2-dioxaborolane 
• 1621575-84-5 (E)-((2-benzylidene-1-(5-methylfuran-2-yl)-4-(thiophen-2-yl)but-3-yn-1-yl)oxy)(tert-butyl)diphenylsilane 
• 37909-88-9 2-([1,1'-biphenyl]-4-yl)thiophene 

Relevant articles and documents

Design and synthesis of boronic acid inhibitors of endothelial lipase

Endothelial lipase (EL) and lipoprotein lipase (LPL) are homologous lipases that act on plasma lipoproteins. EL is predominantly a phospholipase and appears to be a key regulator of plasma HDL-C. LPL is mainly a triglyceride lipase regulating (V)LDL levels. The existing biological data indicate that inhibitors selective for EL over LPL should have anti-atherogenic activity, mainly through increasing plasma HDL-C levels. We report here the synthesis of alkyl, aryl, or acyl-substituted phenylboronic acids that inhibit EL. Many of the inhibitors evaluated proved to be nearly equally potent against both EL and LPL, but several exhibited moderate to good selectivity for EL.