721401-43-0Relevant articles and documents
A new class of fluorescent boronic acids that have extraordinarily high affinities for diols in aqueous solution at physiological pH
Cheng, Yunfeng,Ni, Nanting,Yang, Wenqian,Wang, Binghe
, p. 13528 - 13538 (2010)
The boronic acid group is an important recognition moiety for sensor design. Herein, we report a series of isoquinolinylboronic acids that have extraordinarily high affinities for diol-containing compounds at physiological pH. In addition, 5- and 8-isoquinolinylboronic acids also showed fairly high binding affinities towards D-glucose (Ka=42 and 46M-1, respectively). For the first time, weak but encouraging binding of cis-cyclohexanediol was found for these boronic acids. Such binding was coupled with significant fluorescence changes. Furthermore, 4- and 6- isoquinolinylboronic acids also showed the ability to complex methyl α-D-glucopyranose (Ka=3 and 2M-1, respectively). Be the first! The diol-binding behavior of a series of isoquinolinylboronic acids was investigated by monitoring the changes of their fluorescence intensity (see figure for an example, 6-IQBA=6-isoquinolinylboronic acid). For the first time, a boronic acid derivative that binds cis-cyclohexanediol was identified. Copyright
